FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062216281> ?p ?o ?g. }

• W2062216281 endingPage "122" @default.
• W2062216281 startingPage "116" @default.
• W2062216281 abstract "To evaluate immunohistochemical expression of phosphatase and tensin homolog (PTEN) and mammalian target of rapamycin (mTOR) pathway members in pT1 urothelial carcinomas treated by transurethral resection and to determine if immunohistochemistry can be used to predict prognosis.Formalin-fixed, paraffin-embedded tissue samples from 156 patients with pT1 urothelial carcinoma treated by transurethral resection were used to build 5 tissue microarrays. Tissue microarray sections were stained for PTEN, phosphorylated (phos)-AKT, phos-mTOR, phos-S6, eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), and phos-4EBP1. Patients were monitored after initial treatment (mean, 22.5; median, 16; range, 3-108 months) to detect tumor recurrence, tumor progression, or systemic metastases.During follow-up, 101 patients (65%) showed tumor recurrence, 57 showed tumor progression (37%), and 18 showed systemic metastases (12%). Patients with ≥2 lesions at the initial workup had higher proportions and higher hazard ratios of tumor recurrence, tumor progression, and systemic metastases. Complete loss of PTEN expression was observed in 6 patients (4%), and >80% of the mTOR pathway members showed at least focal positivity. Proportions of tumors with higher levels of PTEN immunohistochemical expression were higher in patients with tumor recurrence (P=.001), tumor progression (P=.05), and systemic metastases (P=.001). Proportions of tumors with lower phos-S6 and low phos-4EBP1 levels were higher in patients with tumor recurrence (P≤.05). Proportions were similar for the remaining biomarkers.Higher levels of PTEN immunohistochemical expression were associated with higher rates of tumor recurrence, tumor progression, and systemic metastases in patients with pT1 urothelial carcinomas treated by transurethral resection." @default.
• W2062216281 created "2016-06-24" @default.
• W2062216281 creator A5007607903 @default.
• W2062216281 creator A5047848345 @default.
• W2062216281 creator A5063195568 @default.
• W2062216281 creator A5064618296 @default.
• W2062216281 creator A5073670316 @default.
• W2062216281 creator A5077295537 @default.
• W2062216281 creator A5088656778 @default.
• W2062216281 date "2013-01-01" @default.
• W2062216281 modified "2023-10-03" @default.
• W2062216281 title "High Levels of Phosphatase and Tensin Homolog Expression Are Associated With Tumor Progression, Tumor Recurrence, and Systemic Metastases in pT1 Urothelial Carcinoma of the Bladder: A Tissue Microarray Study of 156 Patients Treated by Transurethral Resection" @default.
• W2062216281 cites W1498637512 @default.
• W2062216281 cites W1525939594 @default.
• W2062216281 cites W1604908746 @default.
• W2062216281 cites W1977922577 @default.
• W2062216281 cites W1980477405 @default.
• W2062216281 cites W1987057033 @default.
• W2062216281 cites W2017569895 @default.
• W2062216281 cites W2018949682 @default.
• W2062216281 cites W2021343953 @default.
• W2062216281 cites W2029596323 @default.
• W2062216281 cites W2093088536 @default.
• W2062216281 cites W2101967561 @default.
• W2062216281 cites W2104118000 @default.
• W2062216281 cites W2105452584 @default.
• W2062216281 cites W2111709677 @default.
• W2062216281 cites W2127046868 @default.
• W2062216281 cites W2133742377 @default.
• W2062216281 cites W2140629354 @default.
• W2062216281 cites W2147711252 @default.
• W2062216281 cites W2155051272 @default.
• W2062216281 cites W2160714232 @default.
• W2062216281 cites W2162532809 @default.
• W2062216281 doi "https://doi.org/10.1016/j.urology.2012.09.007" @default.
• W2062216281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23273076" @default.
• W2062216281 hasPublicationYear "2013" @default.
• W2062216281 type Work @default.
• W2062216281 sameAs 2062216281 @default.
• W2062216281 citedByCount "17" @default.
• W2062216281 countsByYear W20622162812013 @default.
• W2062216281 countsByYear W20622162812014 @default.
• W2062216281 countsByYear W20622162812015 @default.
• W2062216281 countsByYear W20622162812016 @default.
• W2062216281 countsByYear W20622162812017 @default.
• W2062216281 countsByYear W20622162812018 @default.
• W2062216281 countsByYear W20622162812019 @default.
• W2062216281 countsByYear W20622162812022 @default.
• W2062216281 crossrefType "journal-article" @default.
• W2062216281 hasAuthorship W2062216281A5007607903 @default.
• W2062216281 hasAuthorship W2062216281A5047848345 @default.
• W2062216281 hasAuthorship W2062216281A5063195568 @default.
• W2062216281 hasAuthorship W2062216281A5064618296 @default.
• W2062216281 hasAuthorship W2062216281A5073670316 @default.
• W2062216281 hasAuthorship W2062216281A5077295537 @default.
• W2062216281 hasAuthorship W2062216281A5088656778 @default.
• W2062216281 hasConcept C121608353 @default.
• W2062216281 hasConcept C126322002 @default.
• W2062216281 hasConcept C142724271 @default.
• W2062216281 hasConcept C193270364 @default.
• W2062216281 hasConcept C204232928 @default.
• W2062216281 hasConcept C2777609662 @default.
• W2062216281 hasConcept C2779256057 @default.
• W2062216281 hasConcept C2779549131 @default.
• W2062216281 hasConcept C502942594 @default.
• W2062216281 hasConcept C55493867 @default.
• W2062216281 hasConcept C62478195 @default.
• W2062216281 hasConcept C71924100 @default.
• W2062216281 hasConcept C86554907 @default.
• W2062216281 hasConcept C86803240 @default.
• W2062216281 hasConceptScore W2062216281C121608353 @default.
• W2062216281 hasConceptScore W2062216281C126322002 @default.
• W2062216281 hasConceptScore W2062216281C142724271 @default.
• W2062216281 hasConceptScore W2062216281C193270364 @default.
• W2062216281 hasConceptScore W2062216281C204232928 @default.
• W2062216281 hasConceptScore W2062216281C2777609662 @default.
• W2062216281 hasConceptScore W2062216281C2779256057 @default.
• W2062216281 hasConceptScore W2062216281C2779549131 @default.
• W2062216281 hasConceptScore W2062216281C502942594 @default.
• W2062216281 hasConceptScore W2062216281C55493867 @default.
• W2062216281 hasConceptScore W2062216281C62478195 @default.
• W2062216281 hasConceptScore W2062216281C71924100 @default.
• W2062216281 hasConceptScore W2062216281C86554907 @default.
• W2062216281 hasConceptScore W2062216281C86803240 @default.
• W2062216281 hasIssue "1" @default.
• W2062216281 hasLocation W20622162811 @default.
• W2062216281 hasLocation W20622162812 @default.
• W2062216281 hasOpenAccess W2062216281 @default.
• W2062216281 hasPrimaryLocation W20622162811 @default.
• W2062216281 hasRelatedWork W2555402586 @default.
• W2062216281 hasRelatedWork W2744966301 @default.
• W2062216281 hasRelatedWork W2783050518 @default.
• W2062216281 hasRelatedWork W2792929645 @default.
• W2062216281 hasRelatedWork W2900464141 @default.
• W2062216281 hasRelatedWork W3192317526 @default.
• W2062216281 hasRelatedWork W4289705004 @default.
• W2062216281 hasRelatedWork W4320006642 @default.
• W2062216281 hasRelatedWork W4386773565 @default.

• next