FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062216843> ?p ?o ?g. }

• W2062216843 endingPage "1095" @default.
• W2062216843 startingPage "1086" @default.
• W2062216843 abstract "The efficacy of thrombolytic therapy in patients with submassive pulmonary embolism (PE) remains unclear. Previous meta-analyses have not separately reported the proportion of patients with submassive PE.We assessed the effect of thrombolytic therapy on mortality, recurrent PE, clinical deterioration requiring treatment escalation and bleeding in patients with submassive PE.The MEDLINE, EMBASE and Cochrane Library databases were searched to identify all relevant randomized controlled trials comparing adjunctive thrombolytic therapy with heparin alone as initial treatments in patients with acute submassive PE, and reported 30-day mortality or in-hospital clinical outcomes.A total of 1510 patients were enrolled in this meta-analysis. No significant differences were apparent in the composite endpoint of all-cause death or recurrent PE between the adjunctive thrombolytic therapy arm and the heparin-alone arm (3.1% vs. 5.4%; RR, 0.64 [0.32-1.28]; P = 0.2). Adjunctive thrombolytic therapy significantly reduced the incidence of the composite endpoint of all-cause death or clinical deterioration (3.9% vs. 9.4%; RR, 0.44; P < 0.001). There were no statistically significant associations for major bleeding when adjunctive thrombolytic therapy was compared with heparin therapy alone (6.6% vs. 1.9%; P = 0.2).This meta-analysis shows that adjunctive thrombolytic therapy does not significantly reduce the risk of mortality or recurrent PE in patients with acute submassive PE, but that adjuvant thrombolytic therapy prevents clinical deterioration requiring the escalation of treatment in patients with acute submassive PE. Bleeding risk assessment might be the most successful approach for improving clinical outcomes and patient-specific benefit." @default.
• W2062216843 created "2016-06-24" @default.
• W2062216843 creator A5010491253 @default.
• W2062216843 creator A5017664128 @default.
• W2062216843 creator A5019147041 @default.
• W2062216843 creator A5047525722 @default.
• W2062216843 creator A5058527965 @default.
• W2062216843 date "2014-06-19" @default.
• W2062216843 modified "2023-09-30" @default.
• W2062216843 title "Impact of the efficacy of thrombolytic therapy on the mortality of patients with acute submassive pulmonary embolism: a meta-analysis" @default.
• W2062216843 cites W1592091620 @default.
• W2062216843 cites W1963915169 @default.
• W2062216843 cites W1969992146 @default.
• W2062216843 cites W1978243757 @default.
• W2062216843 cites W1993443958 @default.
• W2062216843 cites W2009344499 @default.
• W2062216843 cites W2011351675 @default.
• W2062216843 cites W2020900565 @default.
• W2062216843 cites W2024687690 @default.
• W2062216843 cites W2036684303 @default.
• W2062216843 cites W2047143536 @default.
• W2062216843 cites W2079302636 @default.
• W2062216843 cites W2085984247 @default.
• W2062216843 cites W2097561850 @default.
• W2062216843 cites W2099381932 @default.
• W2062216843 cites W2100487920 @default.
• W2062216843 cites W2100964332 @default.
• W2062216843 cites W2107941853 @default.
• W2062216843 cites W2110134277 @default.
• W2062216843 cites W2125396330 @default.
• W2062216843 cites W2131286477 @default.
• W2062216843 cites W2152343439 @default.
• W2062216843 cites W2159007980 @default.
• W2062216843 cites W2165618335 @default.
• W2062216843 cites W2166361233 @default.
• W2062216843 cites W2166950143 @default.
• W2062216843 cites W2167502709 @default.
• W2062216843 cites W3168909127 @default.
• W2062216843 cites W4236325521 @default.
• W2062216843 doi "https://doi.org/10.1111/jth.12608" @default.
• W2062216843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24829097" @default.
• W2062216843 hasPublicationYear "2014" @default.
• W2062216843 type Work @default.
• W2062216843 sameAs 2062216843 @default.
• W2062216843 citedByCount "64" @default.
• W2062216843 countsByYear W20622168432015 @default.
• W2062216843 countsByYear W20622168432016 @default.
• W2062216843 countsByYear W20622168432017 @default.
• W2062216843 countsByYear W20622168432018 @default.
• W2062216843 countsByYear W20622168432019 @default.
• W2062216843 countsByYear W20622168432020 @default.
• W2062216843 countsByYear W20622168432021 @default.
• W2062216843 countsByYear W20622168432022 @default.
• W2062216843 countsByYear W20622168432023 @default.
• W2062216843 crossrefType "journal-article" @default.
• W2062216843 hasAuthorship W2062216843A5010491253 @default.
• W2062216843 hasAuthorship W2062216843A5017664128 @default.
• W2062216843 hasAuthorship W2062216843A5019147041 @default.
• W2062216843 hasAuthorship W2062216843A5047525722 @default.
• W2062216843 hasAuthorship W2062216843A5058527965 @default.
• W2062216843 hasBestOaLocation W20622168431 @default.
• W2062216843 hasConcept C126322002 @default.
• W2062216843 hasConcept C168563851 @default.
• W2062216843 hasConcept C203092338 @default.
• W2062216843 hasConcept C2776265017 @default.
• W2062216843 hasConcept C2776478404 @default.
• W2062216843 hasConcept C2777557582 @default.
• W2062216843 hasConcept C3018162438 @default.
• W2062216843 hasConcept C71924100 @default.
• W2062216843 hasConcept C95190672 @default.
• W2062216843 hasConceptScore W2062216843C126322002 @default.
• W2062216843 hasConceptScore W2062216843C168563851 @default.
• W2062216843 hasConceptScore W2062216843C203092338 @default.
• W2062216843 hasConceptScore W2062216843C2776265017 @default.
• W2062216843 hasConceptScore W2062216843C2776478404 @default.
• W2062216843 hasConceptScore W2062216843C2777557582 @default.
• W2062216843 hasConceptScore W2062216843C3018162438 @default.
• W2062216843 hasConceptScore W2062216843C71924100 @default.
• W2062216843 hasConceptScore W2062216843C95190672 @default.
• W2062216843 hasIssue "7" @default.
• W2062216843 hasLocation W20622168431 @default.
• W2062216843 hasLocation W20622168432 @default.
• W2062216843 hasOpenAccess W2062216843 @default.
• W2062216843 hasPrimaryLocation W20622168431 @default.
• W2062216843 hasRelatedWork W2230641066 @default.
• W2062216843 hasRelatedWork W2381982637 @default.
• W2062216843 hasRelatedWork W2914141471 @default.
• W2062216843 hasRelatedWork W3013041320 @default.
• W2062216843 hasRelatedWork W3096683796 @default.
• W2062216843 hasRelatedWork W3132173363 @default.
• W2062216843 hasRelatedWork W3152374296 @default.
• W2062216843 hasRelatedWork W4230986423 @default.
• W2062216843 hasRelatedWork W4292248146 @default.
• W2062216843 hasRelatedWork W4385751578 @default.
• W2062216843 hasVolume "12" @default.
• W2062216843 isParatext "false" @default.
• W2062216843 isRetracted "false" @default.
• W2062216843 magId "2062216843" @default.

• next