FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062219931> ?p ?o ?g. }

• W2062219931 endingPage "1073" @default.
• W2062219931 startingPage "1067" @default.
• W2062219931 abstract "Phosphodiesterase 5 inhibitors (PDE5-Is) are a mainstay in the therapy of erectile dysfunction (ED). The primary end point of clinical efficacy, both in clinical studies and normal practice, is represented by the International Index of Erectile Function (IIEF).To evaluate if platelet cyclic guanosine monophosphate (cGMP) could represent a valuable marker for PDE5-I activity in ED.The study enrolled 46 patients with psychogenic, organic, and mixed ED (20-71 yr of age; IIEF score<26). Patients were randomized to 6 wk of vardenafil, 5 mg/d at bedtime, or placebo.All patients donated two blood samples, one before starting the protocol and the second after 6 wk of treatment.Platelet cGMP was measured in both placebo and vardenafil groups. All the patients completed the IIEF-Erectile Function (EF) domain and the sexual encounter profile (SEP) and underwent visual sexual stimulation (VSS) coupled with Rigiscan. All the measurements were performed prior to starting the protocol and after the 6 wk of treatment.Platelet cGMP production was significantly (p<0.05) elevated in patients taking 5mg vardenafil versus placebo. Vardenafil was not superior to placebo in improving IIEF-EF and SEP scores. Conversely, VSS-Rigiscan revealed a significant amelioration (p<0.028) in the vardenafil group versus placebo. The changes in platelet cGMP level correlated well with VSS-Rigiscan (p=0.0037) but not with IIEF-EF and SEP.Platelet cGMP could represent a relatively simple, reliable, and objective biomarker of PDE5-I activity in ED clinical studies. Larger clinical studies are needed to further validate the use, utility, and limits of this assay." @default.
• W2062219931 created "2016-06-24" @default.
• W2062219931 creator A5006080772 @default.
• W2062219931 creator A5007901747 @default.
• W2062219931 creator A5016113649 @default.
• W2062219931 creator A5023515322 @default.
• W2062219931 creator A5025279590 @default.
• W2062219931 creator A5051536719 @default.
• W2062219931 creator A5073080936 @default.
• W2062219931 creator A5078988686 @default.
• W2062219931 creator A5080243444 @default.
• W2062219931 date "2009-12-01" @default.
• W2062219931 modified "2023-10-17" @default.
• W2062219931 title "Platelet Cyclic Guanosine Monophosphate as a Biomarker of Phosphodiesterase Type 5 Inhibitor Efficacy in the Treatment of Erectile Dysfunction: A Randomized Placebo-Controlled Study" @default.
• W2062219931 cites W1512538844 @default.
• W2062219931 cites W1515660899 @default.
• W2062219931 cites W1974840083 @default.
• W2062219931 cites W1998143238 @default.
• W2062219931 cites W2002583647 @default.
• W2062219931 cites W2023345745 @default.
• W2062219931 cites W2037270274 @default.
• W2062219931 cites W2044720742 @default.
• W2062219931 cites W2049970818 @default.
• W2062219931 cites W2054397342 @default.
• W2062219931 cites W2057525902 @default.
• W2062219931 cites W2062396265 @default.
• W2062219931 cites W2072069294 @default.
• W2062219931 cites W2079630871 @default.
• W2062219931 cites W2079958052 @default.
• W2062219931 cites W2084356164 @default.
• W2062219931 cites W2086240335 @default.
• W2062219931 cites W2103028764 @default.
• W2062219931 cites W2117903697 @default.
• W2062219931 cites W2151802256 @default.
• W2062219931 cites W2159885935 @default.
• W2062219931 cites W2166389885 @default.
• W2062219931 cites W2170497762 @default.
• W2062219931 cites W4297752374 @default.
• W2062219931 doi "https://doi.org/10.1016/j.eururo.2009.09.031" @default.
• W2062219931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19781847" @default.
• W2062219931 hasPublicationYear "2009" @default.
• W2062219931 type Work @default.
• W2062219931 sameAs 2062219931 @default.
• W2062219931 citedByCount "18" @default.
• W2062219931 countsByYear W20622199312012 @default.
• W2062219931 countsByYear W20622199312013 @default.
• W2062219931 countsByYear W20622199312014 @default.
• W2062219931 countsByYear W20622199312016 @default.
• W2062219931 countsByYear W20622199312017 @default.
• W2062219931 countsByYear W20622199312019 @default.
• W2062219931 countsByYear W20622199312020 @default.
• W2062219931 countsByYear W20622199312021 @default.
• W2062219931 countsByYear W20622199312022 @default.
• W2062219931 countsByYear W20622199312023 @default.
• W2062219931 crossrefType "journal-article" @default.
• W2062219931 hasAuthorship W2062219931A5006080772 @default.
• W2062219931 hasAuthorship W2062219931A5007901747 @default.
• W2062219931 hasAuthorship W2062219931A5016113649 @default.
• W2062219931 hasAuthorship W2062219931A5023515322 @default.
• W2062219931 hasAuthorship W2062219931A5025279590 @default.
• W2062219931 hasAuthorship W2062219931A5051536719 @default.
• W2062219931 hasAuthorship W2062219931A5073080936 @default.
• W2062219931 hasAuthorship W2062219931A5078988686 @default.
• W2062219931 hasAuthorship W2062219931A5080243444 @default.
• W2062219931 hasConcept C126322002 @default.
• W2062219931 hasConcept C126894567 @default.
• W2062219931 hasConcept C142724271 @default.
• W2062219931 hasConcept C168563851 @default.
• W2062219931 hasConcept C204787440 @default.
• W2062219931 hasConcept C27081682 @default.
• W2062219931 hasConcept C2776110084 @default.
• W2062219931 hasConcept C2776768464 @default.
• W2062219931 hasConcept C2778537899 @default.
• W2062219931 hasConcept C2778822586 @default.
• W2062219931 hasConcept C2779929075 @default.
• W2062219931 hasConcept C2780816001 @default.
• W2062219931 hasConcept C2780994212 @default.
• W2062219931 hasConcept C519581460 @default.
• W2062219931 hasConcept C535046627 @default.
• W2062219931 hasConcept C71924100 @default.
• W2062219931 hasConcept C74534348 @default.
• W2062219931 hasConceptScore W2062219931C126322002 @default.
• W2062219931 hasConceptScore W2062219931C126894567 @default.
• W2062219931 hasConceptScore W2062219931C142724271 @default.
• W2062219931 hasConceptScore W2062219931C168563851 @default.
• W2062219931 hasConceptScore W2062219931C204787440 @default.
• W2062219931 hasConceptScore W2062219931C27081682 @default.
• W2062219931 hasConceptScore W2062219931C2776110084 @default.
• W2062219931 hasConceptScore W2062219931C2776768464 @default.
• W2062219931 hasConceptScore W2062219931C2778537899 @default.
• W2062219931 hasConceptScore W2062219931C2778822586 @default.
• W2062219931 hasConceptScore W2062219931C2779929075 @default.
• W2062219931 hasConceptScore W2062219931C2780816001 @default.
• W2062219931 hasConceptScore W2062219931C2780994212 @default.
• W2062219931 hasConceptScore W2062219931C519581460 @default.
• W2062219931 hasConceptScore W2062219931C535046627 @default.
• W2062219931 hasConceptScore W2062219931C71924100 @default.
• W2062219931 hasConceptScore W2062219931C74534348 @default.

• next