FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062229504> ?p ?o ?g. }

• W2062229504 endingPage "2445" @default.
• W2062229504 startingPage "2437" @default.
• W2062229504 abstract "In vertebrates, the world of antigenic motifs is matched to large populations of lymphocytes through specific recognition of an epitope by a given receptor unique to a lymphocyte clone. The concept of immune repertoire was proposed to describe this diversity of lymphocyte receptors - Ig and TCR - required by the network of interactions. The immune repertoires became useful tools to describe lymphocyte and receptor populations through the development of the immune system and in pathological situations. Recently, the development of mass technologies made possible a comprehensive survey of immune repertoires at the genome, transcript and protein levels, and some of these techniques have been already adapted to TCR and Ig repertoire analyses. Such approaches generate very big datasets, which necessitates complex and multi-parametric annotations in dedicated databases. They also require new analysis methods, leading to the integration of structure and dynamics of the immune repertoires, at different time scales (immune response, development of the individual, evolution of the species). Such methods may be extended to the analysis of new classes of adaptive-like receptors, which were recently discovered in different invertebrates and in agnathans. Ultimately, they may allow a parallel monitoring of pathogen and immune repertoires addressing the reciprocal influences that decide for the host survival or death. In this review, we first study the characteristics of Ig and TCR repertoires, and we examine several systematic approaches developed for the analysis of these classical immune repertoires at different levels. We then consider examples of the recent developments of modeling and statistical analysis, and we discuss their relevance and their importance for the study of the immune diversity. An extended view of immune repertoires is proposed, integrating the diversity of other receptors involved in immune recognition. Also, we discuss how repertoire studies could link pathogen variation and immune diversity to reveal regulatory patterns and rules driving their co-diversification race." @default.
• W2062229504 created "2016-06-24" @default.
• W2062229504 creator A5000529026 @default.
• W2062229504 creator A5000680638 @default.
• W2062229504 creator A5027123481 @default.
• W2062229504 creator A5056581184 @default.
• W2062229504 creator A5077352590 @default.
• W2062229504 creator A5084282579 @default.
• W2062229504 date "2008-05-01" @default.
• W2062229504 modified "2023-09-25" @default.
• W2062229504 title "New perspectives for large-scale repertoire analysis of immune receptors" @default.
• W2062229504 cites W1180433709 @default.
• W2062229504 cites W1547859938 @default.
• W2062229504 cites W1554543787 @default.
• W2062229504 cites W1666045186 @default.
• W2062229504 cites W1964499368 @default.
• W2062229504 cites W1970688528 @default.
• W2062229504 cites W1971902835 @default.
• W2062229504 cites W1976086277 @default.
• W2062229504 cites W1978273011 @default.
• W2062229504 cites W1979158913 @default.
• W2062229504 cites W1979494106 @default.
• W2062229504 cites W1981041097 @default.
• W2062229504 cites W1985100564 @default.
• W2062229504 cites W1986248194 @default.
• W2062229504 cites W1986974750 @default.
• W2062229504 cites W1990580731 @default.
• W2062229504 cites W1996334950 @default.
• W2062229504 cites W1999164266 @default.
• W2062229504 cites W2001943758 @default.
• W2062229504 cites W2003484701 @default.
• W2062229504 cites W2003574450 @default.
• W2062229504 cites W2008647199 @default.
• W2062229504 cites W2012948249 @default.
• W2062229504 cites W2014097269 @default.
• W2062229504 cites W2014461116 @default.
• W2062229504 cites W2015253560 @default.
• W2062229504 cites W2021106791 @default.
• W2062229504 cites W2023159875 @default.
• W2062229504 cites W2027956702 @default.
• W2062229504 cites W2027972989 @default.
• W2062229504 cites W2036710876 @default.
• W2062229504 cites W2037747846 @default.
• W2062229504 cites W2040992248 @default.
• W2062229504 cites W2042096299 @default.
• W2062229504 cites W2047547740 @default.
• W2062229504 cites W2051374072 @default.
• W2062229504 cites W2051947926 @default.
• W2062229504 cites W2060354653 @default.
• W2062229504 cites W2060687897 @default.
• W2062229504 cites W2060990215 @default.
• W2062229504 cites W2063443064 @default.
• W2062229504 cites W2064008537 @default.
• W2062229504 cites W2066753890 @default.
• W2062229504 cites W2067073663 @default.
• W2062229504 cites W2068983684 @default.
• W2062229504 cites W2071180234 @default.
• W2062229504 cites W2071797481 @default.
• W2062229504 cites W2072546935 @default.
• W2062229504 cites W2076195995 @default.
• W2062229504 cites W2080196315 @default.
• W2062229504 cites W2081825634 @default.
• W2062229504 cites W2087921967 @default.
• W2062229504 cites W2096982215 @default.
• W2062229504 cites W2098252148 @default.
• W2062229504 cites W2098275062 @default.
• W2062229504 cites W2101298293 @default.
• W2062229504 cites W2110988104 @default.
• W2062229504 cites W2114033596 @default.
• W2062229504 cites W2120638695 @default.
• W2062229504 cites W2123459885 @default.
• W2062229504 cites W2125830784 @default.
• W2062229504 cites W2126344995 @default.
• W2062229504 cites W2126450670 @default.
• W2062229504 cites W2129149283 @default.
• W2062229504 cites W2129673360 @default.
• W2062229504 cites W2132742682 @default.
• W2062229504 cites W2139576952 @default.
• W2062229504 cites W2155081037 @default.
• W2062229504 cites W2157441360 @default.
• W2062229504 cites W2158620643 @default.
• W2062229504 cites W2167524807 @default.
• W2062229504 cites W2171283389 @default.
• W2062229504 cites W4230979337 @default.
• W2062229504 cites W4242673342 @default.
• W2062229504 cites W44299764 @default.
• W2062229504 doi "https://doi.org/10.1016/j.molimm.2007.12.018" @default.
• W2062229504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18279958" @default.
• W2062229504 hasPublicationYear "2008" @default.
• W2062229504 type Work @default.
• W2062229504 sameAs 2062229504 @default.
• W2062229504 citedByCount "30" @default.
• W2062229504 countsByYear W20622295042012 @default.
• W2062229504 countsByYear W20622295042013 @default.
• W2062229504 countsByYear W20622295042014 @default.
• W2062229504 countsByYear W20622295042015 @default.
• W2062229504 countsByYear W20622295042017 @default.
• W2062229504 countsByYear W20622295042018 @default.

• next