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- W2062267314 abstract "Macrophages (M phi) are activated by IFN gamma and are important cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous for CMVs to block IFN gamma-induced M phi differentiation. We found that MCMV infection inhibited IFN gamma regulation of many genes in M phi. MCMV infection blocked IFN gamma responses at the level of transcription without blocking Janus kinase/signal transducer and activator of transcription pathway activation and targeted IFN response factor 1- and class II transactivator-dependent and independent promoters. MCMV did not alter basal transcription from IFN gamma-responsive promoters and left the majority of cellular transcripts unchanged even after 48 h of infection. The effects of MCMV infection were specific to chromosomal rather than transiently transfected promoters. Characterization of the IFN gamma-responsive chromosomal class II transactivator promoter revealed that MCMV infection blocked IFN gamma-induced promoter assembly, allowing the virus to transcriptionally paralyze infected M phi responses while allowing basal transcription to proceed." @default.
- W2062267314 created "2016-06-24" @default.
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- W2062267314 date "2003-11-12" @default.
- W2062267314 modified "2023-09-23" @default.
- W2062267314 title "Murine cytomegalovirus paralyzes macrophages by blocking IFNγ-induced promoter assembly" @default.
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- W2062267314 doi "https://doi.org/10.1073/pnas.1835673100" @default.
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