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- W2062276278 abstract "Concentrations of monoamines and metabolites and uric acid were measured inn sequential 15-min microdialysis samples taken from the area of the supraoptic nucleus (SON) in 9 urethane-anaesthetized rats. A decrease of blood pressure of 40 mm Hg was induced by withdrawing 3–4 ml of blood from an indwelling jugular catheter. This decreased of blood ppressure was maintained for 30 min and produced a significant rise in the concentration of noradrenaline (NA) and its metabolite 4-hydroxy-3-methoxyphenyllethan-1, 2-diol (MPHG) and also in 5-hydroxytryptamine (5-HT) and the purine metabolite uric acid (UA). When blood pressure was returned to normal by replacing the withdrawn blood, the concentration of NA, MHPG, 5-HT and UA returned to pre-haemorrhage levels within 15 min. No significant changes in concentrations of dopamine and its metabolites were found, and in 7 control animals sampled 1.5–2 mm away from the SON, in the area of the olfactory tubercle, concentrations of NA, MHPG, 5-HT and UA were not significantly altered by haemorrhage-induced decreases in blood pressure." @default.
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- W2062276278 date "1988-02-01" @default.
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- W2062276278 title "Haemorrhage-induced release of noradrenaline, 5-hydroxytryptamine and uric acid in the supraoptic nucleus of the rat, measured by microdialysis" @default.
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- W2062276278 doi "https://doi.org/10.1016/0006-8993(88)91016-5" @default.
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