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• W2062287958 abstract "Renin-angiotensin-aldosterone systems play a major role in the regulation of human homeostasis mechanism, which are also involved in the development of hypertension and end-organ damage through activation of angiotensin II. Inhibitors of the renin-angiotensin-aldosterone system may reduce the development of end-organ damage to a greater extent than other antihypertensive agents. Aliskiren is the first member of the new class of orally active direct renin inhibitors recently approved by the US Food and Drug Administration for the treatment of hypertension. Aliskiren directly inhibiting the renin and reducing the formation of angiotensin II, which is the most effective mediator involved in the pathogenesis of cardiovascular diseases. The present review mainly focuses on the pharmacodynamics and pharmacokinetics and clinical aspects of aliskiren. In this respect, the review will improve the basic idea to understand the pharmacology of aliskiren, which is useful for the further research in cardiovascular disease.How to Cite this ArticlePubmed StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K. A Novel, Orally Active Renin SRP. 2010; 1(1): 93-98. doi:10.4103/0975-8453.59518Web StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K. A Novel, Orally Active Renin http://www.sysrevpharm.org/?mno=302644636 [Access: March 28, 2021]. doi:10.4103/0975-8453.59518AMA (American Medical Association) StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K. A Novel, Orally Active Renin SRP. 2010; 1(1): 93-98. doi:10.4103/0975-8453.59518Vancouver/ICMJE StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K. A Novel, Orally Active Renin SRP. (2010), [cited March 28, 2021]; 1(1): 93-98. doi:10.4103/0975-8453.59518Harvard StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K (2010) A Novel, Orally Active Renin SRP, 1 (1), 93-98. doi:10.4103/0975-8453.59518Turabian StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K. 2010. A Novel, Orally Active Renin Systematic Reviews in Pharmacy, 1 (1), 93-98. doi:10.4103/0975-8453.59518Chicago StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K. Aliskiren: A Novel, Orally Active Renin Inhibitor. Systematic Reviews in Pharmacy 1 (2010), 93-98. doi:10.4103/0975-8453.59518MLA (The Modern Language Association) StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K. Aliskiren: A Novel, Orally Active Renin Inhibitor. Systematic Reviews in Pharmacy 1.1 (2010), 93-98. Print. doi:10.4103/0975-8453.59518APA (American Psychological Association) StyleMohamed Saleem TS, Jain A, Tarani P, Ravi V, Gauthaman K (2010) A Novel, Orally Active Renin Systematic Reviews in Pharmacy, 1 (1), 93-98. doi:10.4103/0975-8453.59518" @default.
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• W2062287958 date "2010-01-01" @default.
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• W2062287958 title "Aliskiren: A novel, orally active renin inhibitor" @default.
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