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- W2062288891 abstract "In the past decade, Pseudomonas aeruginosa has become a common cause of infection in cancer patients and Pseudomomas sepsis has become the most frequent infection in patients with acute non-lymphocytic leukemia. Although only some patients are colonized with this organism at the time of hospital admission, approximately 50% of ANLL patients will eventually become colonized. Once colonized, subsequent septicemia is the rule in the granulocytopenic patient. Surveillance cultures, in association with serotyping, can assist in detecting the colonized, at-risk patient and aid in establishing and maintaining preventive measures such as environmental decontamination, personnel hygiene, reverse isolation (including sterile water and cooked food), prophylactic non-absorbable antibiotics, and vaccination. Prevention of infection must take high priority because of the high morbidity and mortality of this disease. Until the advent of carbenicillin, death was the rule despite antibiotics such as polymixin B, colistin, and gentamicin which are bactericidal in vitro but not effective in the granulocytopenic patient. Carbenicillin with or without added gentamicin has been shown to consistently achieve an improvement rate of well over 50%. The combination is usually markedly synergistic and resistance, although occurring, has been relatively infrequent. At the present time, we favor this combination for the treatment of Pseudomonas aeruginosa infections in granulocytopenic cancer patients and favor the addition of cephalothin for initial empiric therapy before culture results are available." @default.
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- W2062288891 date "1973-06-01" @default.
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- W2062288891 title "Pseudomonas septicemia: Incidence, epidemiology, prevention and therapy in patients with advanced cancer" @default.
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- W2062288891 doi "https://doi.org/10.1016/0014-2964(73)90110-2" @default.
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