FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062300520> ?p ?o ?g. }

• W2062300520 endingPage "2653" @default.
• W2062300520 startingPage "2649" @default.
• W2062300520 abstract "A strategy for the proteolytic fragmentation of human IgM has been developed. This method is called cold pepsin digestion because of its unique feature of achieving restricted peptic cleavages at 4 degrees and pH 4.0. Cold pepsin digestion has been applied successfully to produce an Fv fragment from 14 human IgM proteins. The Fv fragment consists of the heavy chain variable domain (VH) and the light chain variable domain (VL) held together by strong noncovalent interaction. Thus, each Fv fragment contains one intact antigen-binding site and represents the minimal active fragment derivable from an antibody molecule. A series of other structurally and functionally important fragments were also isolated and characterized. Two basic digestion pathways were recognized; these mainly reflect the relative accessibility of five sets of major interdomain cleavage sites." @default.
• W2062300520 created "2016-06-24" @default.
• W2062300520 creator A5073957277 @default.
• W2062300520 creator A5075514719 @default.
• W2062300520 date "1978-06-01" @default.
• W2062300520 modified "2023-10-16" @default.
• W2062300520 title "Cold pepsin digestion: a novel method to produce the Fv fragment from human immunoglobulin M." @default.
• W2062300520 cites W1504642308 @default.
• W2062300520 cites W1585662641 @default.
• W2062300520 cites W1599893120 @default.
• W2062300520 cites W1609609875 @default.
• W2062300520 cites W1625660792 @default.
• W2062300520 cites W1766587231 @default.
• W2062300520 cites W1779616392 @default.
• W2062300520 cites W188154833 @default.
• W2062300520 cites W1980045399 @default.
• W2062300520 cites W2000551064 @default.
• W2062300520 cites W2018582187 @default.
• W2062300520 cites W2024671988 @default.
• W2062300520 cites W2038897746 @default.
• W2062300520 cites W2045130717 @default.
• W2062300520 cites W2046374934 @default.
• W2062300520 cites W2058360756 @default.
• W2062300520 cites W2061867098 @default.
• W2062300520 cites W2073879684 @default.
• W2062300520 cites W2084254139 @default.
• W2062300520 doi "https://doi.org/10.1073/pnas.75.6.2649" @default.
• W2062300520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/392620" @default.
• W2062300520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/351613" @default.
• W2062300520 hasPublicationYear "1978" @default.
• W2062300520 type Work @default.
• W2062300520 sameAs 2062300520 @default.
• W2062300520 citedByCount "39" @default.
• W2062300520 countsByYear W20623005202013 @default.
• W2062300520 countsByYear W20623005202017 @default.
• W2062300520 crossrefType "journal-article" @default.
• W2062300520 hasAuthorship W2062300520A5073957277 @default.
• W2062300520 hasAuthorship W2062300520A5075514719 @default.
• W2062300520 hasBestOaLocation W20623005201 @default.
• W2062300520 hasConcept C104317684 @default.
• W2062300520 hasConcept C151730666 @default.
• W2062300520 hasConcept C153911025 @default.
• W2062300520 hasConcept C159654299 @default.
• W2062300520 hasConcept C16311235 @default.
• W2062300520 hasConcept C167625842 @default.
• W2062300520 hasConcept C175156509 @default.
• W2062300520 hasConcept C181199279 @default.
• W2062300520 hasConcept C185592680 @default.
• W2062300520 hasConcept C18903297 @default.
• W2062300520 hasConcept C191015642 @default.
• W2062300520 hasConcept C199360897 @default.
• W2062300520 hasConcept C2776235265 @default.
• W2062300520 hasConcept C2781357212 @default.
• W2062300520 hasConcept C2909223937 @default.
• W2062300520 hasConcept C3019223276 @default.
• W2062300520 hasConcept C36394416 @default.
• W2062300520 hasConcept C41008148 @default.
• W2062300520 hasConcept C43369102 @default.
• W2062300520 hasConcept C43617362 @default.
• W2062300520 hasConcept C54355233 @default.
• W2062300520 hasConcept C55493867 @default.
• W2062300520 hasConcept C85630698 @default.
• W2062300520 hasConcept C86803240 @default.
• W2062300520 hasConceptScore W2062300520C104317684 @default.
• W2062300520 hasConceptScore W2062300520C151730666 @default.
• W2062300520 hasConceptScore W2062300520C153911025 @default.
• W2062300520 hasConceptScore W2062300520C159654299 @default.
• W2062300520 hasConceptScore W2062300520C16311235 @default.
• W2062300520 hasConceptScore W2062300520C167625842 @default.
• W2062300520 hasConceptScore W2062300520C175156509 @default.
• W2062300520 hasConceptScore W2062300520C181199279 @default.
• W2062300520 hasConceptScore W2062300520C185592680 @default.
• W2062300520 hasConceptScore W2062300520C18903297 @default.
• W2062300520 hasConceptScore W2062300520C191015642 @default.
• W2062300520 hasConceptScore W2062300520C199360897 @default.
• W2062300520 hasConceptScore W2062300520C2776235265 @default.
• W2062300520 hasConceptScore W2062300520C2781357212 @default.
• W2062300520 hasConceptScore W2062300520C2909223937 @default.
• W2062300520 hasConceptScore W2062300520C3019223276 @default.
• W2062300520 hasConceptScore W2062300520C36394416 @default.
• W2062300520 hasConceptScore W2062300520C41008148 @default.
• W2062300520 hasConceptScore W2062300520C43369102 @default.
• W2062300520 hasConceptScore W2062300520C43617362 @default.
• W2062300520 hasConceptScore W2062300520C54355233 @default.
• W2062300520 hasConceptScore W2062300520C55493867 @default.
• W2062300520 hasConceptScore W2062300520C85630698 @default.
• W2062300520 hasConceptScore W2062300520C86803240 @default.
• W2062300520 hasIssue "6" @default.
• W2062300520 hasLocation W20623005201 @default.
• W2062300520 hasLocation W20623005202 @default.
• W2062300520 hasLocation W20623005203 @default.
• W2062300520 hasLocation W20623005204 @default.
• W2062300520 hasOpenAccess W2062300520 @default.
• W2062300520 hasPrimaryLocation W20623005201 @default.
• W2062300520 hasRelatedWork W156213250 @default.
• W2062300520 hasRelatedWork W1682075913 @default.
• W2062300520 hasRelatedWork W1911878331 @default.
• W2062300520 hasRelatedWork W2007266295 @default.

• next