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- W2062300622 abstract "For the past 50 years, the parallel-group, randomized, placebo- or comparator-controlled trial has been the standard for testing the efficacy of medications. Randomized controlled trials (RCTs) in patients with late-life depression typically include modifications specific for this age-group, for example, lower starting dose, slower dose escalation, and longer trial duration. These changes reflect the widely held beliefs that, compared with younger patients, elderly depressed patients are more sensitive to side effects and take longer to remit. The current models of the RCT have served us well. Nonetheless, the findings of recent clinical trials and analyses of extant data mandate fundamental revisions in the design and conduct of RCTs." @default.
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- W2062300622 date "2002-09-01" @default.
- W2062300622 modified "2023-10-17" @default.
- W2062300622 title "Clinical Trials in Late-Life Depression: Revisited" @default.
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- W2062300622 doi "https://doi.org/10.1097/00019442-200209000-00002" @default.
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