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• W2062300934 endingPage "1639" @default.
• W2062300934 startingPage "1627" @default.
• W2062300934 abstract "Cyclin D1 is a key regulator of the G1 phase of the cell cycle. Inhibition of cyclin D1 function results in cell cycle arrest, whereas unregulated expression of the protein accelerates G1. Cyclin D1 is localized to the nucleus during G1. We found that during repair DNA synthesis, subsequent to UV-induced DNA damage, G1 cells readily lost their cyclin D1 while the proliferating cell nuclear antigen (PCNA) tightly associated with nuclear structures. Microinjection of cyclin D1 antisense accelerated DNA repair, whereas overexpression of cyclin D1 prevented DNA repair and the relocation of PCNA after DNA damage. Coexpression of cyclin D1 with its primary catalytic subunit, Cdk4, or with Cdk2, also prevented repair. In contrast, coexpression of PCNA, which is also a cyclin D1-associated protein, restored the ability of cells to repair their DNA. Acute overexpression of cyclin D1 in fibroblasts prevented them from entering S phase. Again, these effects were abolished by coexpression of cyclin D1 together with PCNA, but not with Cdk4 or Cdk2. Altogether, these results indicate that down-regulation of cyclin D1 is necessary for PCNA relocation and repair DNA synthesis as well as for the start of DNA replication. Cyclin D1 appears to be an essential component of a G1-checkpoint." @default.
• W2062300934 created "2016-06-24" @default.
• W2062300934 creator A5034919044 @default.
• W2062300934 creator A5037541103 @default.
• W2062300934 creator A5052320455 @default.
• W2062300934 creator A5058848968 @default.
• W2062300934 date "1994-07-15" @default.
• W2062300934 modified "2023-09-25" @default.
• W2062300934 title "Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts." @default.
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• W2062300934 doi "https://doi.org/10.1101/gad.8.14.1627" @default.
• W2062300934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7958844" @default.
• W2062300934 hasPublicationYear "1994" @default.
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