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• W2062321820 abstract "Chronic treatment of adult male rats with TRH (1 or 10 mg/kg IP) for 5 or 9 days failed to alter the activity of tyrosine hydroxylase (TH), the enzyme regulating the rate-limiting step in catecholamine biosynthesis. In contrast, as previously described, chronic reserpine administration (0.5 mg/kg IP: 9 days) resulted in a significant rise in TH activity in midbrain, hypothalamus, pons-medulla and forebrain. These results suggest that the enhanced brain norepinephrine turnover reported to occur after treatment with TRH is not due to synthesis of new TH enzyme protein." @default.
• W2062321820 created "2016-06-24" @default.
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• W2062321820 date "1977-04-01" @default.
• W2062321820 modified "2023-09-27" @default.
• W2062321820 title "Lack of effect of chronically administered thyrotropin-releasing hormone (TRH) on regional rat brain tyrosine hydroxylase activity" @default.
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• W2062321820 doi "https://doi.org/10.1016/0091-3057(77)90186-1" @default.
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