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- W2062334181 abstract "Pretreatment with dibenamine (25 mg/kg sc 48 and 24 hr before the administration of a hepatotoxic agent) protected rats against the hepatotoxicity of CCl4, thioacetamide, or dimethylnitrosamine, but not against allyl alcohol or bromobenzene. Protection was evident from reduced activity of plasma glutamic-pyruvic transaminase and reduced liver necrosis as demonstrated by histologic evaluations. In rats pretreated with dibenamine, LD50 values for CCl4 and thioacetamide were elevated and liver triglycerides after CCl4 and dimethylnitrosamine were reduced. Dibenamine protection against hepatotoxicity did not correlate with alpha-adrenergic receptor blockade. Similar pretreatment with 3 other alpha-adrenergic blocking agents, tolazoline, phenoxybenzamine, and EEDQ (N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline), failed to protect rats against CCl4-induced hepatotoxicity." @default.
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- W2062334181 date "1974-02-01" @default.
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- W2062334181 title "Reduction by pretreatment with dibenamine of hepatotoxicity induced by carbon tetrachloride, thioacetamide or dimethylnitrosamine" @default.
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- W2062334181 doi "https://doi.org/10.1016/0041-008x(74)90209-9" @default.
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