Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062337302> ?p ?o ?g. }
- W2062337302 endingPage "332" @default.
- W2062337302 startingPage "317" @default.
- W2062337302 abstract "The effect of caffeine on UV-irradiated Chinese hamster cells in vitro was studied on the cellular and molecular levels. Caffeine (1 mM) was shown to decrease the colony-forming ability and the frequencies of spontaneous and UV-induced mutations in Chinese hamster cells. The effect of caffeine in reducing the frequency of UV-induced mutations was demonstrated only if caffeine was present in the culture medium during the first post-irradiation cell division. Using alkaline sucrose gradient centrifugation, both parental and newly synthesized DNA in UV-irradiated and unirradiated cells were studied in the presence and absence of caffeine. Caffeine affected the sedimentation profile of DNA synthesized in UV-irradiated cells but not in unirradiated cells. Caffeine had no apparent effect on the incorporation of [3H]-thymidine into DNA of control or UV-irradiated cells, nor on the small amount of excision of UV-induced pyrimidine dimers. These results may be interpreted by a hypothesis that caffeine inhibits a certain S-phase specific, post-replication, dark-repair mechanism. The hamster and perhaps other rodent cells exposed to low doses of UV are capable of DNA replication, by-passing the non-excised pyrimidine dimers. This postulated repair process probably involves de novo DNA synthesis to seal the gaps in the nascent strand. This repair may be also responsible for the enzymatic production of mutations." @default.
- W2062337302 created "2016-06-24" @default.
- W2062337302 creator A5001846206 @default.
- W2062337302 creator A5049296315 @default.
- W2062337302 date "1973-05-01" @default.
- W2062337302 modified "2023-09-26" @default.
- W2062337302 title "Inhibition of repair of UV-damaged DNA by caffeine and mutation induction in Chinese hamster cells" @default.
- W2062337302 cites W1682461530 @default.
- W2062337302 cites W17405798 @default.
- W2062337302 cites W1897633092 @default.
- W2062337302 cites W1969928839 @default.
- W2062337302 cites W1973652547 @default.
- W2062337302 cites W1979827357 @default.
- W2062337302 cites W1984459901 @default.
- W2062337302 cites W1985000280 @default.
- W2062337302 cites W1987687723 @default.
- W2062337302 cites W1988061351 @default.
- W2062337302 cites W1991497781 @default.
- W2062337302 cites W1995256079 @default.
- W2062337302 cites W2001332771 @default.
- W2062337302 cites W2005340570 @default.
- W2062337302 cites W2014724783 @default.
- W2062337302 cites W2015063478 @default.
- W2062337302 cites W2016202627 @default.
- W2062337302 cites W2020957031 @default.
- W2062337302 cites W2021496938 @default.
- W2062337302 cites W2023796599 @default.
- W2062337302 cites W2024176364 @default.
- W2062337302 cites W2025306280 @default.
- W2062337302 cites W2025585188 @default.
- W2062337302 cites W2029130914 @default.
- W2062337302 cites W2034066736 @default.
- W2062337302 cites W2037647656 @default.
- W2062337302 cites W2041093743 @default.
- W2062337302 cites W2041149390 @default.
- W2062337302 cites W2041976716 @default.
- W2062337302 cites W2043007932 @default.
- W2062337302 cites W2047781433 @default.
- W2062337302 cites W2054981160 @default.
- W2062337302 cites W2056214580 @default.
- W2062337302 cites W2063872129 @default.
- W2062337302 cites W2068354895 @default.
- W2062337302 cites W2073219664 @default.
- W2062337302 cites W2075193271 @default.
- W2062337302 cites W2079198418 @default.
- W2062337302 cites W2079822498 @default.
- W2062337302 cites W2085433304 @default.
- W2062337302 cites W2121543188 @default.
- W2062337302 cites W2128903096 @default.
- W2062337302 cites W2134840452 @default.
- W2062337302 cites W2158493122 @default.
- W2062337302 cites W2159797579 @default.
- W2062337302 cites W2166661146 @default.
- W2062337302 cites W2176849002 @default.
- W2062337302 cites W2206749554 @default.
- W2062337302 cites W2243990155 @default.
- W2062337302 cites W2324524056 @default.
- W2062337302 cites W2326820676 @default.
- W2062337302 cites W2914083752 @default.
- W2062337302 cites W4205585483 @default.
- W2062337302 cites W4239134116 @default.
- W2062337302 doi "https://doi.org/10.1016/0009-2797(73)90046-x" @default.
- W2062337302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4736056" @default.
- W2062337302 hasPublicationYear "1973" @default.
- W2062337302 type Work @default.
- W2062337302 sameAs 2062337302 @default.
- W2062337302 citedByCount "96" @default.
- W2062337302 countsByYear W20623373022013 @default.
- W2062337302 countsByYear W20623373022022 @default.
- W2062337302 crossrefType "journal-article" @default.
- W2062337302 hasAuthorship W2062337302A5001846206 @default.
- W2062337302 hasAuthorship W2062337302A5049296315 @default.
- W2062337302 hasConcept C102306862 @default.
- W2062337302 hasConcept C104317684 @default.
- W2062337302 hasConcept C134018914 @default.
- W2062337302 hasConcept C134935766 @default.
- W2062337302 hasConcept C1491633281 @default.
- W2062337302 hasConcept C153911025 @default.
- W2062337302 hasConcept C167975912 @default.
- W2062337302 hasConcept C202751555 @default.
- W2062337302 hasConcept C2777108182 @default.
- W2062337302 hasConcept C2777755551 @default.
- W2062337302 hasConcept C2778500429 @default.
- W2062337302 hasConcept C2778575167 @default.
- W2062337302 hasConcept C501734568 @default.
- W2062337302 hasConcept C54355233 @default.
- W2062337302 hasConcept C552990157 @default.
- W2062337302 hasConcept C55493867 @default.
- W2062337302 hasConcept C64241487 @default.
- W2062337302 hasConcept C73573662 @default.
- W2062337302 hasConcept C81885089 @default.
- W2062337302 hasConcept C85813293 @default.
- W2062337302 hasConcept C86803240 @default.
- W2062337302 hasConceptScore W2062337302C102306862 @default.
- W2062337302 hasConceptScore W2062337302C104317684 @default.
- W2062337302 hasConceptScore W2062337302C134018914 @default.
- W2062337302 hasConceptScore W2062337302C134935766 @default.
- W2062337302 hasConceptScore W2062337302C1491633281 @default.