Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062344144> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2062344144 endingPage "S169" @default.
- W2062344144 startingPage "S169" @default.
- W2062344144 abstract "Few studies have addressed the issue of COH for fertility preservation in breast cancer patients. Letrozole is currently required in order to limit the estrogen levels increase. In France, the use of letrozole in this specific area is not allowed. The aim of this study is to evaluate the benefit/risk of the ovarian stimulation without letrozole for oocyte freezing in young breast cancer patients undergoing adjuvant chemotherapy. Prospective observational study. A total of 45 young breast cancer patients were prospectively included before adjuvant chemotherapy. The inclusion criteria for being eligible to COH were: age under 40, complete surgery, absence of metastases. Lymph node status, presence of hormonal receptors, BRCA 1/2 were not exclusion criteria. COH protocol consisted in the association of r-FSH and antagonist with a GnRh agonist triggering. r-FSH starting dose varied from 150 to 450 IU. Patients were then enrolled in a systematic oncologic and reproductive follow-up for 3 consecutive years. 13 patients declined the proposal of fertility preservation and 4 were not eligible because of suspect uptakes during positron emission tomography. 28 patients underwent COH. Mean age was 30.3 +/-3.4. Mean r-FSH dose was 271 +/- 92 IU. The average number of days of supra-physiologic E2 levels (i-e triggering day - day 6) was 5 +/-1. Peak E2 levels ranged from 149 to 5314 pg/ml with a mean of 1793 +/- 1173 pg/ml. An average of 10 oocytes +/- 5.6 was retrieved. The mean number of vitrified oocytes was respectively 7 +/-4.9. Time between surgery and chemotherapy was 46.6 days (18-69). Mean duration of follow-up after the end of chemotherapy was 10 months +/- 11. No recurrences were observed during the study period. There was one case of moderate OHSS and 3 cycle cancellations for insufficient response. To date, no oncologic adverse effects were noted. These preliminary results have to be confirmed in a larger population through a much long-term follow-up." @default.
- W2062344144 created "2016-06-24" @default.
- W2062344144 creator A5001731251 @default.
- W2062344144 creator A5034741737 @default.
- W2062344144 creator A5039458712 @default.
- W2062344144 creator A5041806820 @default.
- W2062344144 creator A5079834835 @default.
- W2062344144 creator A5089337136 @default.
- W2062344144 date "2013-09-01" @default.
- W2062344144 modified "2023-10-14" @default.
- W2062344144 title "Fertility preservation by controlled ovarian hyperstimulation (COH) without letrozole in young breast cancer patients before adjuvant chemotherapy: preliminary results" @default.
- W2062344144 doi "https://doi.org/10.1016/j.fertnstert.2013.07.1467" @default.
- W2062344144 hasPublicationYear "2013" @default.
- W2062344144 type Work @default.
- W2062344144 sameAs 2062344144 @default.
- W2062344144 citedByCount "1" @default.
- W2062344144 countsByYear W20623441442019 @default.
- W2062344144 crossrefType "journal-article" @default.
- W2062344144 hasAuthorship W2062344144A5001731251 @default.
- W2062344144 hasAuthorship W2062344144A5034741737 @default.
- W2062344144 hasAuthorship W2062344144A5039458712 @default.
- W2062344144 hasAuthorship W2062344144A5041806820 @default.
- W2062344144 hasAuthorship W2062344144A5079834835 @default.
- W2062344144 hasAuthorship W2062344144A5089337136 @default.
- W2062344144 hasBestOaLocation W20623441441 @default.
- W2062344144 hasConcept C121608353 @default.
- W2062344144 hasConcept C126322002 @default.
- W2062344144 hasConcept C126894567 @default.
- W2062344144 hasConcept C143998085 @default.
- W2062344144 hasConcept C2776600139 @default.
- W2062344144 hasConcept C2777176818 @default.
- W2062344144 hasConcept C2777688143 @default.
- W2062344144 hasConcept C2777904497 @default.
- W2062344144 hasConcept C2778478619 @default.
- W2062344144 hasConcept C2778575703 @default.
- W2062344144 hasConcept C2778812593 @default.
- W2062344144 hasConcept C2778894405 @default.
- W2062344144 hasConcept C2779234561 @default.
- W2062344144 hasConcept C2779448150 @default.
- W2062344144 hasConcept C2908647359 @default.
- W2062344144 hasConcept C29456083 @default.
- W2062344144 hasConcept C518429986 @default.
- W2062344144 hasConcept C530470458 @default.
- W2062344144 hasConcept C54355233 @default.
- W2062344144 hasConcept C71315377 @default.
- W2062344144 hasConcept C71924100 @default.
- W2062344144 hasConcept C86803240 @default.
- W2062344144 hasConcept C99454951 @default.
- W2062344144 hasConceptScore W2062344144C121608353 @default.
- W2062344144 hasConceptScore W2062344144C126322002 @default.
- W2062344144 hasConceptScore W2062344144C126894567 @default.
- W2062344144 hasConceptScore W2062344144C143998085 @default.
- W2062344144 hasConceptScore W2062344144C2776600139 @default.
- W2062344144 hasConceptScore W2062344144C2777176818 @default.
- W2062344144 hasConceptScore W2062344144C2777688143 @default.
- W2062344144 hasConceptScore W2062344144C2777904497 @default.
- W2062344144 hasConceptScore W2062344144C2778478619 @default.
- W2062344144 hasConceptScore W2062344144C2778575703 @default.
- W2062344144 hasConceptScore W2062344144C2778812593 @default.
- W2062344144 hasConceptScore W2062344144C2778894405 @default.
- W2062344144 hasConceptScore W2062344144C2779234561 @default.
- W2062344144 hasConceptScore W2062344144C2779448150 @default.
- W2062344144 hasConceptScore W2062344144C2908647359 @default.
- W2062344144 hasConceptScore W2062344144C29456083 @default.
- W2062344144 hasConceptScore W2062344144C518429986 @default.
- W2062344144 hasConceptScore W2062344144C530470458 @default.
- W2062344144 hasConceptScore W2062344144C54355233 @default.
- W2062344144 hasConceptScore W2062344144C71315377 @default.
- W2062344144 hasConceptScore W2062344144C71924100 @default.
- W2062344144 hasConceptScore W2062344144C86803240 @default.
- W2062344144 hasConceptScore W2062344144C99454951 @default.
- W2062344144 hasIssue "3" @default.
- W2062344144 hasLocation W20623441441 @default.
- W2062344144 hasOpenAccess W2062344144 @default.
- W2062344144 hasPrimaryLocation W20623441441 @default.
- W2062344144 hasRelatedWork W2137638125 @default.
- W2062344144 hasRelatedWork W2581543549 @default.
- W2062344144 hasRelatedWork W2734614567 @default.
- W2062344144 hasRelatedWork W2780830128 @default.
- W2062344144 hasRelatedWork W2972634993 @default.
- W2062344144 hasRelatedWork W2975970316 @default.
- W2062344144 hasRelatedWork W3119252349 @default.
- W2062344144 hasRelatedWork W3131683854 @default.
- W2062344144 hasRelatedWork W3191177376 @default.
- W2062344144 hasRelatedWork W4283773116 @default.
- W2062344144 hasVolume "100" @default.
- W2062344144 isParatext "false" @default.
- W2062344144 isRetracted "false" @default.
- W2062344144 magId "2062344144" @default.
- W2062344144 workType "article" @default.