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• W2062345788 abstract "Proteins from the cytochrome P-450 CYP4A gene family metabolise hormones such as prostaglandins and other fatty acids, and are induced by peroxisome proliferators such as the hypolipidaemic drugs clofibrate and ciprofibrate. In order or better understand the function and regulation of these enzymes we have cloned a murine cDNA, Cyp4a-10, whose deduced amino acid sequence shares 92% sequence identity with rat CYP4A1. The developmental and hormonal regulation of this protein and other members of the murine Cyp4a gene family weren then studied using a polyclonal antibody to rat CYP4A1. The expression of Cyp4a proteins in liver and kidney develop gradually form birth and are sexually in mature animals; growth hormone appears to be involved in regulating expression of hepatic Cyp4a proteins. The administration of phenobarbital and dexamethasone affected the expression of Cyp4a proteins in the liver, but not in the kidney, where testosterone was the key regulatory factor, demonsrating interesting tissue-specific effects in the regulation of these enzymes." @default.
• W2062345788 created "2016-06-24" @default.
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• W2062345788 date "1994-07-01" @default.
• W2062345788 modified "2023-10-18" @default.
• W2062345788 title "Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hornonal regulation in liver and kidney" @default.
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• W2062345788 doi "https://doi.org/10.1016/0304-4165(94)90134-1" @default.
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