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- W2062364008 abstract "Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein–coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23 /P2Y9), and LPA5 (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis. Developmental Dynamics 237:3280–3294, 2008. © 2008 Wiley-Liss, Inc." @default.
- W2062364008 created "2016-06-24" @default.
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- W2062364008 date "2008-11-01" @default.
- W2062364008 modified "2023-10-17" @default.
- W2062364008 title "Expression patterns of the lysophospholipid receptor genes during mouse early development" @default.
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- W2062364008 doi "https://doi.org/10.1002/dvdy.21736" @default.
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