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• W2062368844 abstract "Editorials1 June 1979Bromocriptine and Pituitary DisordersJ. KELLETT, M.D., H. G. FRIESEN, M.D.J. KELLETT, M.D.Search for more papers by this author, H. G. FRIESEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-980 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere have been four important medical advances that in a short time have combined to focus attention on the pituitary gland and disorders affecting it. These include a better appreciation of the neuroendocrine mechanisms that regulate pituitary hormone secretion, the recognition that hyperprolactinemia is implicated in approximately 25% of cases of secondary amenorrhea, improved radiologic techniques that allow the detection of pituitary microadenomas that previously went unrecognized, and restoration of normal endocrine function in a high percentage of patients after complete removal of these tumors using the transsphenoidal route. The early identification of these tumors is therefore important.The introduction...References1. SPARKDICKSTEIN RG: Bromocriptine and endocrine disorders. Ann Intern Med 90:949-956, 1979 LinkGoogle Scholar2. FLÜCKIGER E: Drugs and the control of prolactin secretion, in Fourth Tenovus Workshop on Prolactin and Carcinogenesis. Cardiff, Wales, Alpha Omega Alpha Publishing, 1972, p. 162 Google Scholar3. DEL RE BRUNDEL POZODE GRANDIFRIESENHINSELMANNWYSS REPHNH: Prolactin inhibition and suppression of puerperal lactation by a-br-ergocryptine (CB-154): a comparison with estrogen. Obstet Gynecol 41:884-890, 1973 MedlineGoogle Scholar4. VAN LOON G: A defect in catecholamine neurons in patients with prolactin-secreting pituitary adenoma. Lancet 2:868-871, 1978 CrossrefMedlineGoogle Scholar5. MALARKEYGROSHANGMILO WJG: Defective dopaminergic regulation of prolactin secretion in a rat pituitary tumor cell line. Nature 266:640-641, 1977 CrossrefMedlineGoogle Scholar6. RAYMONDBEAULIEULABRIEBOISSIER VMFJ: Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release. Science 200:1173-1175, 1978 CrossrefMedlineGoogle Scholar7. FUXELOFSTROMHOKFELTFERLANDANDERSSENAGNATIEINEROTHGUSTAFSSONSKETT KATLKLPJP: Influence of central catecholamines on LHRH-containing pathways. Clin Obstet Gynecol 5:251-269, 1978 Google Scholar8. FRIESEN H: Human prolactin. Ann R Coll Physicians and Surg Canada 11:275-281, 1978 Google Scholar9. SWANSONDU BOULAY HG: Borderline variants of the normal pituitary fossa. Br J Radiol 48:366-369, 1975 CrossrefMedlineGoogle Scholar10. VON WERDERBRENDELEVERSMANNFAHLBUSCHMULLERRJOSK KCTROH: Medical therapy of hyperprolactinemia and Cushing's disease associated with pituitary hormones, in International Symposium of Microadenomas, edited by FAGLIA G, GIOVANELLI MA. Milan, Academic Press, 1978 Google Scholar11. POLATTIBOLISRAVIGNI-PROBIZERBARUFFINICAVOLLERI FPMAA: Treatment of hyperprolactinemic amenorrhea by intermittent administration of bromocryptine (CB-154). Am J Obstet Gynecol 131:792-796, 1978 CrossrefMedlineGoogle Scholar12. KOLATA G: Behavioral teratology: birth defects of the mind. Science 202:732-734, 1978 CrossrefMedlineGoogle Scholar13. HARDYBEAUREGARDROBERT JHF: Prolactin-secreting pituitary adenomas transsphenoidal microsurgical treatment, in Progress in Prolactin Physiology and Pathology. Proceedings of the International Symposium on Prolactin, Nice France, 20-23 October 1977, edited by ROBYN C, HARTER M. New York, Elsevier/North-Holland Biomedical Press, 1978, p. 362 Google Scholar14. BESSERTHORNERWASSDONIACHCANTICURLINGGRUDZINISKASSETCHELL GMJIGMJM: Absence of uterine neoplasia in patients on bromocryptine. Br Med J 2:868, 1977 CrossrefMedlineGoogle Scholar15. DEL POZOLANCRANJAN EI: Clinical use of drugs modifying the release of anterior pituitary hormones, in Frontiers in Neuroendocrinology, edited by GANONG WF, MARTINI L. New York, Raven Press, 1978, p. 207 Google Scholar16. LENTONSOBOWALECOOKE EOI: Prolactin concentrations in ovulatory but infertile women: treatment with bromocriptine. Br Med J 2:1179-1181, 1977 CrossrefMedlineGoogle Scholar17. LEWISDUNNBONEWALDSEAVEYVANDERLAAN UJLBW: A naturally occurring structural variant of human growth hormone. J Biol Chem 253:2679-2687, 1978 CrossrefMedlineGoogle Scholar18. HELSEHAUGENBOHMER JHT: Bromocriptine treatment in acromegaly: clinical and biochemical effects. Acta Endocrinol 86:464-472, 1977 CrossrefMedlineGoogle Scholar19. ESKILDSENSVENDSENVANGNERUP PPLJ: Long term treatment of acromegaly with bromocriptine. Acta Endocrinol 87:687-700, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. KELLETT, M.D.; H. G. FRIESEN, M.D.Affiliations: Department of Physiology University of Manitoba Winnipeg, Manitoba Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProlactinomas and Dopamine AgonistsPituitary TumorsThe mode of action of bromocriptineDrug Therapy in Renal Failure: Dosing Guidelines for Adults Part II: Sedatives, Hypnotics, and Tranquilizers; Cardiovascular, Antihypertensive, and Diuretic Agents; Miscellaneous AgentsWILLIAM M. BENNETT, M.D., RICHARD S. MUTHER, M.D., RICHARD A. PARKER, M.D., PETER FEIG, M.D., GAIL MORRISON, M.D., THOMAS A. GOLPER, M.D., IRWIN SINGER, M.D. 1 June 1979Volume 90, Issue 6Page: 980-982KeywordsPituitary glandProlactin ePublished: 1 December 2008 Issue Published: 1 June 1979 PDF downloadLoading ..." @default.
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