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• W2062382022 abstract "This study tested the combination of vascular brachytherapy (VBT) and self-expanding Wallstent implantation in coronary lesions of patients at high risk for restenosis as assessed angiographically by quantitative coronary analysis and by 3-dimensional intravascular ultrasound analysis. Twenty-nine “de novo” lesions were managed with a self-expanding stent alone (n = 19) or with a self-expanding stent after β-VBT (n = 10) in 27 patients who had been identified by high levels of plasma angiotensin-converting enzyme as being prone to myointimal growth after stent implantation. At 6 months, the increase in stent strut diameter was similar in the 2 groups by quantitative coronary analysis and 3-dimensional intravascular ultrasound (Δ mean stent strut diameter −0.33 ± 0.3 vs −0.40 ± 0.3 mm, p = 0.5; Δ stent area −11.8 ± 6.1 vs −12.0 ± 6.1 mm2, p = 0.9; Δ stent volume −96.9 ± 112 vs −83.5 ± 73 mm3, p = 0.7; for groups treated with VBT and self-expanding stents and only self-expanding stents, respectively). In-stent neointimal proliferation was decreased in the group treated with VBT and self-expanding stents (minimal luminal diameter 2.5 ± 0.8 vs 1.88 ± 0.8 mm, p = 0.04) by quantitative coronary analysis (minimal luminal area 6.7 ± 2.5 vs 4.1 ± 1.9 mm2, p = 0.01), by intravascular ultrasound, and proliferation volume (84.6 ± 66.4 vs 159.2 ± 103.5 mm3, p = 0.05) by 3-dimensional intravascular ultrasound. Positive vessel and luminal remodelings were observed in 50% of the group treated with VBT and self-expanding stents and in 11% of the group treated only with self-expanding stents (p = 0.02). The combined use of VBT and self-expanding stents is a novel approach that enlarges vascular lumen by preventing vessel constriction and neointimal proliferation. The feasibility and good results of this experimental approach suggest that the simultaneous use of these 2 technologies may be an interesting alternative for difficult vascular districts with high restenosis rates, such as peripheral circulation in the lower limbs. This study tested the combination of vascular brachytherapy (VBT) and self-expanding Wallstent implantation in coronary lesions of patients at high risk for restenosis as assessed angiographically by quantitative coronary analysis and by 3-dimensional intravascular ultrasound analysis. Twenty-nine “de novo” lesions were managed with a self-expanding stent alone (n = 19) or with a self-expanding stent after β-VBT (n = 10) in 27 patients who had been identified by high levels of plasma angiotensin-converting enzyme as being prone to myointimal growth after stent implantation. At 6 months, the increase in stent strut diameter was similar in the 2 groups by quantitative coronary analysis and 3-dimensional intravascular ultrasound (Δ mean stent strut diameter −0.33 ± 0.3 vs −0.40 ± 0.3 mm, p = 0.5; Δ stent area −11.8 ± 6.1 vs −12.0 ± 6.1 mm2, p = 0.9; Δ stent volume −96.9 ± 112 vs −83.5 ± 73 mm3, p = 0.7; for groups treated with VBT and self-expanding stents and only self-expanding stents, respectively). In-stent neointimal proliferation was decreased in the group treated with VBT and self-expanding stents (minimal luminal diameter 2.5 ± 0.8 vs 1.88 ± 0.8 mm, p = 0.04) by quantitative coronary analysis (minimal luminal area 6.7 ± 2.5 vs 4.1 ± 1.9 mm2, p = 0.01), by intravascular ultrasound, and proliferation volume (84.6 ± 66.4 vs 159.2 ± 103.5 mm3, p = 0.05) by 3-dimensional intravascular ultrasound. Positive vessel and luminal remodelings were observed in 50% of the group treated with VBT and self-expanding stents and in 11% of the group treated only with self-expanding stents (p = 0.02). The combined use of VBT and self-expanding stents is a novel approach that enlarges vascular lumen by preventing vessel constriction and neointimal proliferation. The feasibility and good results of this experimental approach suggest that the simultaneous use of these 2 technologies may be an interesting alternative for difficult vascular districts with high restenosis rates, such as peripheral circulation in the lower limbs." @default.
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• W2062382022 date "2004-11-01" @default.
• W2062382022 modified "2023-09-25" @default.
• W2062382022 title "Angiographic and three-dimensional intravascular ultrasound analysis of combined intracoronary beta radiation and self-expanding stent implantation in human coronary arteries" @default.
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• W2062382022 doi "https://doi.org/10.1016/j.amjcard.2004.07.106" @default.
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