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• W2062382342 abstract "MicroRNAs (miRNAs) and short interfering RNAs (siRNAs) are classes of regulatory small RNA molecules, ranging from 18 to 24 nucleotides in length, whose roles in development and disease are becoming increasingly recognized. They function by altering the stability or translational efficiency of messenger RNAs (mRNAs) with which they share sequence complementarity, and are predicted to affect up to one-third of all human genes. Computer algorithms and microarray data estimate the presence of nearly 1000 human miRNAs, and direct examination of candidate miRNAs has validated their involvement in various cancers, disorders of neuronal development, cardiac hypertrophy, and skin diseases such as psoriasis. This article reviews the history of miRNA and siRNA discovery, key aspects of their biogenesis and mechanism of action, and known connections to human health, with an emphasis on their roles in skin development and disease. Learning objectives After completing this learning activity, participants should be able to summarize the relevance of microRNAs in development and disease, explain the molecular steps of how small RNAs regulate their targets within the human cell, and discuss the role of small RNAs in the diagnosis and treatment of disease. MicroRNAs (miRNAs) and short interfering RNAs (siRNAs) are classes of regulatory small RNA molecules, ranging from 18 to 24 nucleotides in length, whose roles in development and disease are becoming increasingly recognized. They function by altering the stability or translational efficiency of messenger RNAs (mRNAs) with which they share sequence complementarity, and are predicted to affect up to one-third of all human genes. Computer algorithms and microarray data estimate the presence of nearly 1000 human miRNAs, and direct examination of candidate miRNAs has validated their involvement in various cancers, disorders of neuronal development, cardiac hypertrophy, and skin diseases such as psoriasis. This article reviews the history of miRNA and siRNA discovery, key aspects of their biogenesis and mechanism of action, and known connections to human health, with an emphasis on their roles in skin development and disease. After completing this learning activity, participants should be able to summarize the relevance of microRNAs in development and disease, explain the molecular steps of how small RNAs regulate their targets within the human cell, and discuss the role of small RNAs in the diagnosis and treatment of disease. CME examinationJournal of the American Academy of DermatologyVol. 59Issue 5Preview Full-Text PDF" @default.
• W2062382342 created "2016-06-24" @default.
• W2062382342 creator A5013016915 @default.
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• W2062382342 date "2008-11-01" @default.
• W2062382342 modified "2023-09-27" @default.
• W2062382342 title "Small RNAs in development and disease" @default.
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• W2062382342 cites W1964631913 @default.
• W2062382342 cites W1964668704 @default.
• W2062382342 cites W1967342065 @default.
• W2062382342 cites W1974134624 @default.
• W2062382342 cites W1977728725 @default.
• W2062382342 cites W1985563073 @default.
• W2062382342 cites W1991320836 @default.
• W2062382342 cites W1992086750 @default.
• W2062382342 cites W2008652897 @default.
• W2062382342 cites W2008759459 @default.
• W2062382342 cites W2009644747 @default.
• W2062382342 cites W2010807493 @default.
• W2062382342 cites W2015396326 @default.
• W2062382342 cites W2019950862 @default.
• W2062382342 cites W2032323486 @default.
• W2062382342 cites W2034432190 @default.
• W2062382342 cites W2038082731 @default.
• W2062382342 cites W2041992860 @default.
• W2062382342 cites W2045178946 @default.
• W2062382342 cites W2046109186 @default.
• W2062382342 cites W2047529648 @default.
• W2062382342 cites W2053445868 @default.
• W2062382342 cites W2057562212 @default.
• W2062382342 cites W2059557106 @default.
• W2062382342 cites W2066204446 @default.
• W2062382342 cites W2068010171 @default.
• W2062382342 cites W2075860675 @default.
• W2062382342 cites W2080232689 @default.
• W2062382342 cites W2083381199 @default.
• W2062382342 cites W2084001490 @default.
• W2062382342 cites W2092018614 @default.
• W2062382342 cites W2094786733 @default.
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• W2062382342 cites W2105882193 @default.
• W2062382342 cites W2111401971 @default.
• W2062382342 cites W2116322544 @default.
• W2062382342 cites W2130979840 @default.
• W2062382342 cites W2133105825 @default.
• W2062382342 cites W2135314242 @default.
• W2062382342 cites W2135613885 @default.
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• W2062382342 cites W2145299132 @default.
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• W2062382342 doi "https://doi.org/10.1016/j.jaad.2008.08.017" @default.
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