Matches in SemOpenAlex for { <https://semopenalex.org/work/W206238902> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W206238902 abstract "Abstract : This study examined the role of oxygen in amphotericin B-induced killing of Leishmania braziliensis panamensis promastigotes and Candida albicans. In the first phase of the study, we explored the effects of high oxygen tensions on the lethal effects of three reduction-oxidation cycling drugs: amphotericin B, menadione, and phenazine methosulfate. Promastigotes were exposed to the above drugs under normoxic, hyperoxic (100% 02 at 101.3 kPa), ot hyperbaric hyperoxic (100% 02 at 253.3 kPa) conditions. After 24 h incubation at 27 deg C, viable promastigotes stained with fluorescein diacetate and were counted using epifluorescence microscopy. Hyperbaric hyperoxia alone (PO2 = 229 kPa) was as effective as AmB alone (0.2 uM); both killed 80% of the original inoculum. AmB killed more promastigotes in a hyperbaric hyperoxic environment than in normoxic (PO2 = 21.1 kPa) or hyperoxic conditions (PO2 = 91.7 kPa). High oxygen tensions did not alter the lethal effects of either menadione or phenazine methosulfate. In the second phase of the study, the effects of hypoxia on AmB killing in Leishmania and yeast cells were investigated. Leishmania promastigotes were exposed to AmB (0.1 and 1.0 uM) in media with dissolved PO2s of 22 mmHg (hypoxia) and 150 mmHg (normoxia) for two h at 27 deg C. Following incubation, promastigotes were stained as above and viable organisms counted. Promustigote, hyperoxia, hyperbaric hyperoxia, amphotericin B, Leishmania." @default.
- W206238902 created "2016-06-24" @default.
- W206238902 creator A5021563098 @default.
- W206238902 creator A5050983550 @default.
- W206238902 creator A5064976058 @default.
- W206238902 creator A5068686735 @default.
- W206238902 creator A5089880091 @default.
- W206238902 date "1992-06-30" @default.
- W206238902 modified "2023-09-26" @default.
- W206238902 title "Augmented Oxygen-Dependent Killing of Leishmania." @default.
- W206238902 hasPublicationYear "1992" @default.
- W206238902 type Work @default.
- W206238902 sameAs 206238902 @default.
- W206238902 citedByCount "0" @default.
- W206238902 crossrefType "journal-article" @default.
- W206238902 hasAuthorship W206238902A5021563098 @default.
- W206238902 hasAuthorship W206238902A5050983550 @default.
- W206238902 hasAuthorship W206238902A5064976058 @default.
- W206238902 hasAuthorship W206238902A5068686735 @default.
- W206238902 hasAuthorship W206238902A5089880091 @default.
- W206238902 hasConcept C136764020 @default.
- W206238902 hasConcept C143701427 @default.
- W206238902 hasConcept C153911025 @default.
- W206238902 hasConcept C178790620 @default.
- W206238902 hasConcept C181199279 @default.
- W206238902 hasConcept C185592680 @default.
- W206238902 hasConcept C25642318 @default.
- W206238902 hasConcept C2779548794 @default.
- W206238902 hasConcept C2779629538 @default.
- W206238902 hasConcept C2779965811 @default.
- W206238902 hasConcept C2780672939 @default.
- W206238902 hasConcept C2780917455 @default.
- W206238902 hasConcept C2781092759 @default.
- W206238902 hasConcept C2781095387 @default.
- W206238902 hasConcept C28859421 @default.
- W206238902 hasConcept C41008148 @default.
- W206238902 hasConcept C540031477 @default.
- W206238902 hasConcept C55493867 @default.
- W206238902 hasConcept C71928629 @default.
- W206238902 hasConcept C86803240 @default.
- W206238902 hasConcept C89423630 @default.
- W206238902 hasConceptScore W206238902C136764020 @default.
- W206238902 hasConceptScore W206238902C143701427 @default.
- W206238902 hasConceptScore W206238902C153911025 @default.
- W206238902 hasConceptScore W206238902C178790620 @default.
- W206238902 hasConceptScore W206238902C181199279 @default.
- W206238902 hasConceptScore W206238902C185592680 @default.
- W206238902 hasConceptScore W206238902C25642318 @default.
- W206238902 hasConceptScore W206238902C2779548794 @default.
- W206238902 hasConceptScore W206238902C2779629538 @default.
- W206238902 hasConceptScore W206238902C2779965811 @default.
- W206238902 hasConceptScore W206238902C2780672939 @default.
- W206238902 hasConceptScore W206238902C2780917455 @default.
- W206238902 hasConceptScore W206238902C2781092759 @default.
- W206238902 hasConceptScore W206238902C2781095387 @default.
- W206238902 hasConceptScore W206238902C28859421 @default.
- W206238902 hasConceptScore W206238902C41008148 @default.
- W206238902 hasConceptScore W206238902C540031477 @default.
- W206238902 hasConceptScore W206238902C55493867 @default.
- W206238902 hasConceptScore W206238902C71928629 @default.
- W206238902 hasConceptScore W206238902C86803240 @default.
- W206238902 hasConceptScore W206238902C89423630 @default.
- W206238902 hasLocation W2062389021 @default.
- W206238902 hasOpenAccess W206238902 @default.
- W206238902 hasPrimaryLocation W2062389021 @default.
- W206238902 hasRelatedWork W1636511273 @default.
- W206238902 hasRelatedWork W2351002109 @default.
- W206238902 hasRelatedWork W2359116883 @default.
- W206238902 hasRelatedWork W2361339166 @default.
- W206238902 hasRelatedWork W2366898942 @default.
- W206238902 hasRelatedWork W2372584355 @default.
- W206238902 hasRelatedWork W2389967751 @default.
- W206238902 hasRelatedWork W3028863804 @default.
- W206238902 hasRelatedWork W3031626677 @default.
- W206238902 hasRelatedWork W2184093203 @default.
- W206238902 isParatext "false" @default.
- W206238902 isRetracted "false" @default.
- W206238902 magId "206238902" @default.
- W206238902 workType "article" @default.