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- W2062401244 abstract "i-OHAP, a major metabolite of aprindine (AP), was isolated by TLC from rat feces and identified as N-13-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol, based on 1H-NMR, the H-H correlation spectroscopy (COSY) spectrum, MS and LC-MS. Its structure was also confirmed by comparison with the synthesized compound. The hydroxy group of i-OHAP was located at the 5-position of the indan ring. AP is a prochiral compound, and the metabolism of AP to i-OHAP was stereoselective. The ratio of (+)/(-)-i-OHAP in rat feces and in human urine was about 5 and 15, respectively." @default.
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- W2062401244 date "1998-01-01" @default.
- W2062401244 modified "2023-09-23" @default.
- W2062401244 title "Isolation of a Major Metabolite (i-OHAP) of Aprindine and Its Identification as N-(3-(N,N-Diethylamino)propyl)-N-phenyl-2-aminoindan-5-ol." @default.
- W2062401244 doi "https://doi.org/10.1248/bpb.21.530" @default.
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