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• W2062404054 abstract "1 Airway hyper-reactivity to inhaled adenosine, mediated via mast cell activation, is a cardinal feature of asthma. Animal models have been developed in several species to mimic this phenomenon, but only in the rat has a mast cell involvement been clearly defined. In this study, a model of ovalbumin-induced adenosine hyper-reactivity was developed in BALB/c mice to determine whether mast cells are involved in this phenomenon. 2 Sensitised mice were challenged one, two or three times, on a daily basis, and airway responses to the stable adenosine analogue NECA (5′-N-ethylcarboxamido adenosine) determined 4 and 24 h after each challenge. Airway hyper-reactivity was observed in ovalbumin-challenged mice 4 h after a single challenge and to a minor extent 24 h after a single challenge and 4 h after two challenges. 3 Cromolyn (20 mg ml−1), given by aerosol an hour before the NECA provocation, fully inhibited the airway hyper-reactivity observed 4 h after a single allergen challenge, suggesting a role for mast cells in this response. The airway space cellular inflammation was not affected by cromolyn. 4 As observed in human asthma, an acute treatment with steroid (budesonide 3 mg kg−1, given an hour before the allergen challenge) inhibited the NECA airway hyper-reactivity and significantly inhibited the airway space cellular inflammation. 5 These data suggest that the ovalbumin-challenged BALB/c mice can be considered as a suitable model to study the adenosine-induced airway hyper-reactivity phenomenon observed in human asthma. British Journal of Pharmacology (2005) 145, 845–852. doi:10.1038/sj.bjp.0706271" @default.
• W2062404054 created "2016-06-24" @default.
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• W2062404054 date "2005-08-01" @default.
• W2062404054 modified "2023-10-18" @default.
• W2062404054 title "Mast cell involvement in the adenosine mediated airway hyper-reactivity in a murine model of ovalbumin-induced lung inflammation" @default.
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• W2062404054 doi "https://doi.org/10.1038/sj.bjp.0706271" @default.
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