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• W2062421388 abstract "Epidemiologic studies and experiments with mouse models suggest that polyaromatic hydrocarbons contained in, among others, diesel exhaust particles can promote the development of allergy.Because IL-4 organizes allergic responses in vivo, we have investigated whether pyrene, a major compound of diesel exhaust particles, can affect the production of IL-4.IL-4 production by primary human T cells was assessed by ELISA and messenger RNA transcription was detected by Northern blotting. Activation of the IL-4 promoter was tested in reporter gene assays with transiently transfected cell lines.Pyrene induced transcription of IL-4 messenger RNA and expression of IL-4 protein in primary human T cells. Pyrene, but not related polyaromatic hydrocarbons, enhanced basal transcription of the human and mouse IL-4 promoter.Our results suggest that pyrene may promote allergic diseases by inducing the production of IL-4." @default.
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• W2062421388 date "2000-04-01" @default.
• W2062421388 modified "2023-10-13" @default.
• W2062421388 title "The environmental pollutant pyrene induces the production of IL-4" @default.
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• W2062421388 doi "https://doi.org/10.1067/mai.2000.105124" @default.
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