FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062456579> ?p ?o ?g. }

• W2062456579 endingPage "4858" @default.
• W2062456579 startingPage "4851" @default.
• W2062456579 abstract "Receptor-specific agonists of the extracellular calcium-sensing receptor (CaSR) potentiate glucose-induced insulin secretion, an effect similar to that of glucagon-like peptide-1 (GLP-1). We have sequenced the full open reading frame of the CaSR from rat insulinoma (INS-1) cells and find that the predicted amino acid sequence of the receptor is identical with that of the receptor from the parathyroid gland. This receptor couples to both Gq/11 and Gi/o, and this dual coupling may partly explain the varying effects of nonspecific agonists on secretion reported previously. l-Histidine (l-His) increases the sensitivity of the CaSR to extracellular Ca2+ and potentiates glucose-dependent insulin secretion from INS-1 cells. This potentiation is partially inhibited at low extracellular [Ca2+] where the CaSR is ineffective. Coexpression of the CaSR and GLP-1 receptor (GLP-1R) produces a pertussis toxin-sensitive inhibition of GLP-1-induced cAMP production in response to elevated extracellular [Ca2+]. However, l-His potentiates cAMP response element reporter activity in INS-1 cells and in human embryonic kidney-293 cells expressing either the GLP-1R alone or the CaSR and GLP-1R. INS-1 cells express the RNA for the CaSR at a lower level than that for the GLP-1R. This difference in expression level of the receptors may explain the potentiation of insulin secretion by l-His despite coupling of the CaSR to Gi/o. In conclusion, l-His can potentiate both GLP-1R- and CaSR-activated signaling pathways, and these effects may play a role in the potentiation of glucose-induced insulin secretion in response to meals containing protein in addition to carbohydrates and fat." @default.
• W2062456579 created "2016-06-24" @default.
• W2062456579 creator A5034913449 @default.
• W2062456579 creator A5053141753 @default.
• W2062456579 date "2003-11-01" @default.
• W2062456579 modified "2023-09-26" @default.
• W2062456579 title "Regulation of Glucagon-Like Peptide-1 Receptor and Calcium-Sensing Receptor Signaling by l-Histidine" @default.
• W2062456579 cites W135145353 @default.
• W2062456579 cites W1970958676 @default.
• W2062456579 cites W1972820231 @default.
• W2062456579 cites W1980224304 @default.
• W2062456579 cites W1992045485 @default.
• W2062456579 cites W2002960170 @default.
• W2062456579 cites W2009441758 @default.
• W2062456579 cites W2011190447 @default.
• W2062456579 cites W2015832594 @default.
• W2062456579 cites W2017518223 @default.
• W2062456579 cites W2021221131 @default.
• W2062456579 cites W2024743516 @default.
• W2062456579 cites W2038539392 @default.
• W2062456579 cites W2056860785 @default.
• W2062456579 cites W2058859904 @default.
• W2062456579 cites W2059364146 @default.
• W2062456579 cites W2064825935 @default.
• W2062456579 cites W2065238612 @default.
• W2062456579 cites W2065390805 @default.
• W2062456579 cites W2066040631 @default.
• W2062456579 cites W2072058124 @default.
• W2062456579 cites W2077973233 @default.
• W2062456579 cites W2103871176 @default.
• W2062456579 cites W2106856165 @default.
• W2062456579 cites W2107277218 @default.
• W2062456579 cites W2132210046 @default.
• W2062456579 cites W2139625901 @default.
• W2062456579 cites W2153170303 @default.
• W2062456579 cites W2315674654 @default.
• W2062456579 cites W2434645087 @default.
• W2062456579 doi "https://doi.org/10.1210/en.2003-0498" @default.
• W2062456579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12959987" @default.
• W2062456579 hasPublicationYear "2003" @default.
• W2062456579 type Work @default.
• W2062456579 sameAs 2062456579 @default.
• W2062456579 citedByCount "17" @default.
• W2062456579 countsByYear W20624565792012 @default.
• W2062456579 countsByYear W20624565792014 @default.
• W2062456579 countsByYear W20624565792015 @default.
• W2062456579 countsByYear W20624565792016 @default.
• W2062456579 countsByYear W20624565792018 @default.
• W2062456579 countsByYear W20624565792019 @default.
• W2062456579 countsByYear W20624565792021 @default.
• W2062456579 crossrefType "journal-article" @default.
• W2062456579 hasAuthorship W2062456579A5034913449 @default.
• W2062456579 hasAuthorship W2062456579A5053141753 @default.
• W2062456579 hasBestOaLocation W20624565791 @default.
• W2062456579 hasConcept C126322002 @default.
• W2062456579 hasConcept C134018914 @default.
• W2062456579 hasConcept C142590548 @default.
• W2062456579 hasConcept C170493617 @default.
• W2062456579 hasConcept C185280430 @default.
• W2062456579 hasConcept C185592680 @default.
• W2062456579 hasConcept C2778563252 @default.
• W2062456579 hasConcept C2778938600 @default.
• W2062456579 hasConcept C2779306644 @default.
• W2062456579 hasConcept C2781208988 @default.
• W2062456579 hasConcept C28406088 @default.
• W2062456579 hasConcept C49773422 @default.
• W2062456579 hasConcept C519063684 @default.
• W2062456579 hasConcept C71924100 @default.
• W2062456579 hasConcept C80631254 @default.
• W2062456579 hasConcept C86803240 @default.
• W2062456579 hasConcept C95444343 @default.
• W2062456579 hasConceptScore W2062456579C126322002 @default.
• W2062456579 hasConceptScore W2062456579C134018914 @default.
• W2062456579 hasConceptScore W2062456579C142590548 @default.
• W2062456579 hasConceptScore W2062456579C170493617 @default.
• W2062456579 hasConceptScore W2062456579C185280430 @default.
• W2062456579 hasConceptScore W2062456579C185592680 @default.
• W2062456579 hasConceptScore W2062456579C2778563252 @default.
• W2062456579 hasConceptScore W2062456579C2778938600 @default.
• W2062456579 hasConceptScore W2062456579C2779306644 @default.
• W2062456579 hasConceptScore W2062456579C2781208988 @default.
• W2062456579 hasConceptScore W2062456579C28406088 @default.
• W2062456579 hasConceptScore W2062456579C49773422 @default.
• W2062456579 hasConceptScore W2062456579C519063684 @default.
• W2062456579 hasConceptScore W2062456579C71924100 @default.
• W2062456579 hasConceptScore W2062456579C80631254 @default.
• W2062456579 hasConceptScore W2062456579C86803240 @default.
• W2062456579 hasConceptScore W2062456579C95444343 @default.
• W2062456579 hasIssue "11" @default.
• W2062456579 hasLocation W20624565791 @default.
• W2062456579 hasLocation W20624565792 @default.
• W2062456579 hasOpenAccess W2062456579 @default.
• W2062456579 hasPrimaryLocation W20624565791 @default.
• W2062456579 hasRelatedWork W1974106130 @default.
• W2062456579 hasRelatedWork W1986101904 @default.
• W2062456579 hasRelatedWork W1990422519 @default.
• W2062456579 hasRelatedWork W2026928593 @default.
• W2062456579 hasRelatedWork W2070076315 @default.

• next