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• W2062457774 abstract "The incidence of sister chromatid exchange (SCE) was investigated in the lymphocytes of control women, pregnant women, and women using oral contraceptives after culture at 37 degrees C and 40 degrees C. At 37 degrees C, the mean frequency of SCE (MEAN +/- S.E.) was found to be 7.91 +/- 0.30 in pregnant women and 8.53 +/- 0.29 in oral contraceptive users which were significantly higher than the SCE value of 5.56 +/- 0.21 found in control women. Increase in growth temperature to 40 degrees C elevated the SCE frequency to 11.86 +/- 0.44 in pregnant women, 12.76 +/- 0.46 in oral contraceptive users and 7.24 +/- 0.26 in control women. These data indicate that there is a differential induction of SCEs following increased cell culture temperature in the lymphocytes of pregnant women and oral contraceptive users, compared with control women.The incidence of sister chromatid exchange (SCE) was investigated in the lymphocytes of 44 pregnant women, 51 users of oral contraceptives (OCs), and 38 controls after culture at 37 C and 40 C. All study subjects were healthy adult females who were not occupationally exposed to mutagens, were nonsmokers, and had no recent viral infection or radiation exposure. At the normal growth temperature of 37 C, the frequency of SCEs/cell was 7.91 + or - 0.30 in pregnant women, 8.53 + or - 0.29 in OC users, and 5.56 + or - 0.21 in controls. When the growth temperature was elevated to 40 C, there was a further increase in the frequency of SCE in all 3 groups: 11.86 + or - 0.44 in pregnant women, 12.76 + or - 0.46 in OC users, and 7.24 + or - 0.26 in controls. Given the significant differences between SCE frequencies of pregnant women and OC users on one hand and controls on the other hand, it can be implied that chromosomes of pregnant women and women using hormonal contraceptives are more susceptible to the damage induced by increases in cell culture temperature. There are also indications that the higher level of hormones present in the blood of pregnant women and OC users may play an important role in increasing the sensitivity of their lymphocytes of genetic damage. The increased induction of SCEs following increased cell culture temperature in pregnant women and OC users may be attributable to the increased efficiency of such a temperature-dependent gyrase-like enzyme on the 1 hand and to the increased mutagenic activity of estrogen or its metabolites on the other hand." @default.
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• W2062457774 title "Sister chromatid exchanges in the lymphocytes of control women, pregnant women, and women taking oral contraceptives: Effects of cell culture temperature" @default.
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• W2062457774 doi "https://doi.org/10.1002/em.2860120204" @default.
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