FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062463352> ?p ?o ?g. }

• W2062463352 endingPage "234" @default.
• W2062463352 startingPage "234" @default.
• W2062463352 abstract "Previous studies in vitro have shown that nitric oxide (NO) reacts with superoxide anion to form a strong oxidant, peroxinitrite, that can cause lipid peroxidation. The present study tests the hypothesis that inhibition of nitric oxide synthase by N-omega-nitro-L-arginine (NNLA) will result in decreased free radical generation and brain cell membrane lipid peroxidation during hypoxia in vivo. Twenty anesthetized, ventilated piglets were divided into 4 groups: Vn: vehicle (pH adjusted saline), normoxia; Vh: vehicle, hypoxia: Nn: NNLA, normoxia and Nh: NNLA, hypoxia. Vehicle and NNLA treated groups received 40 mg/Kg NNLA or its vehicle, respectively. Hypoxia induced with FiO2 0.07 for 60 min resulted in PaO2 18-20 mmHg, and documented biochemically by decreased ATP and phosphocreatine. Cerebral cortex was homogenized inα-phenyl-N-tert-butylnitrone (PBN). The PBN adducts were extracted in toluene and electron spin resonance spectroscopy (ESR) performed. Signal height (intensity) of spectrum divided by tissue weight is expressed in mm/g tissue. The character of the spin adduct signal was similar to that from the chemically produced alkoxyl radical. Free radical intensity in groups Vn. Vh. Nn and Nh was 11.6 ± 4.4, 27.7 ± 18.8, 15.3 ± 6.5, and 11.6 ± 2.0, respectively. Lipid peroxidation products (conjugated dienes) in groups Vn, Vh, Nn and Nh were 15 ± 34, 149 ± 46, 53± 55, and 99 ± 29 nmole/g brain, respectively. The results show that free radical production and lipid peroxidation products were increased in Vh compared with Vn and Nn (p<0.05). However, administration of NNLA significantly reduced the formation of predominantly alkoxyl radicals in the hypoxic brain (p<0.05) and reduced lipid peroxidation products. These data suggest that NO is a limiting factor in the reaction of peroxinitrite-mediated lipid peroxidation, presumably by the fact that NOS blockade directly inhibit peroxinitrite formation by reducing the one reactant, NO. (Funded by NIH20337, MOD #94-0135, UCPR-506-93)" @default.
• W2062463352 created "2016-06-24" @default.
• W2062463352 creator A5009123179 @default.
• W2062463352 creator A5020710328 @default.
• W2062463352 creator A5031122578 @default.
• W2062463352 creator A5037763404 @default.
• W2062463352 creator A5083814874 @default.
• W2062463352 date "1996-04-01" @default.
• W2062463352 modified "2023-10-18" @default.
• W2062463352 title "NITRIC OXIDE SYNTHASE INHIBITION ON FREE RADICAL GENERATION DURING CEREBRAL HYPOXIA IN NEWBORN PIGLETS. ▴ 1389" @default.
• W2062463352 doi "https://doi.org/10.1203/00006450-199604001-01412" @default.
• W2062463352 hasPublicationYear "1996" @default.
• W2062463352 type Work @default.
• W2062463352 sameAs 2062463352 @default.
• W2062463352 citedByCount "2" @default.
• W2062463352 crossrefType "journal-article" @default.
• W2062463352 hasAuthorship W2062463352A5009123179 @default.
• W2062463352 hasAuthorship W2062463352A5020710328 @default.
• W2062463352 hasAuthorship W2062463352A5031122578 @default.
• W2062463352 hasAuthorship W2062463352A5037763404 @default.
• W2062463352 hasAuthorship W2062463352A5083814874 @default.
• W2062463352 hasBestOaLocation W20624633521 @default.
• W2062463352 hasConcept C178790620 @default.
• W2062463352 hasConcept C185592680 @default.
• W2062463352 hasConcept C2777622882 @default.
• W2062463352 hasConcept C42219234 @default.
• W2062463352 hasConcept C519581460 @default.
• W2062463352 hasConcept C540031477 @default.
• W2062463352 hasConcept C55493867 @default.
• W2062463352 hasConcept C71924100 @default.
• W2062463352 hasConcept C7836513 @default.
• W2062463352 hasConceptScore W2062463352C178790620 @default.
• W2062463352 hasConceptScore W2062463352C185592680 @default.
• W2062463352 hasConceptScore W2062463352C2777622882 @default.
• W2062463352 hasConceptScore W2062463352C42219234 @default.
• W2062463352 hasConceptScore W2062463352C519581460 @default.
• W2062463352 hasConceptScore W2062463352C540031477 @default.
• W2062463352 hasConceptScore W2062463352C55493867 @default.
• W2062463352 hasConceptScore W2062463352C71924100 @default.
• W2062463352 hasConceptScore W2062463352C7836513 @default.
• W2062463352 hasLocation W20624633521 @default.
• W2062463352 hasOpenAccess W2062463352 @default.
• W2062463352 hasPrimaryLocation W20624633521 @default.
• W2062463352 hasRelatedWork W2012326377 @default.
• W2062463352 hasRelatedWork W2015636956 @default.
• W2062463352 hasRelatedWork W2037592408 @default.
• W2062463352 hasRelatedWork W2075791279 @default.
• W2062463352 hasRelatedWork W2166910723 @default.
• W2062463352 hasRelatedWork W2360086888 @default.
• W2062463352 hasRelatedWork W2371548989 @default.
• W2062463352 hasRelatedWork W2389576412 @default.
• W2062463352 hasRelatedWork W2461353996 @default.
• W2062463352 hasRelatedWork W4248190669 @default.
• W2062463352 hasVolume "39" @default.
• W2062463352 isParatext "false" @default.
• W2062463352 isRetracted "false" @default.
• W2062463352 magId "2062463352" @default.
• W2062463352 workType "article" @default.