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- W2062472783 abstract "Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the prepulse, termed “prepulse inhibition” (PPI), is widely used in translational models to understand the biology of brain‑based inhibitory mechanisms and their deficiency in neuropsychiatric disorders. In 1981, four published reports with “prepulse inhibition” as an index term were listed on Medline; over the past 5 years, new published Medline reports with “prepulse inhibition” as an index term have appeared at a rate exceeding once every 2.7 days (n = 678). Most of these reports focus on the use of PPI in translational models of impaired sensorimotor gating in schizophrenia. This rapid expansion and broad application of PPI as a tool for understanding schizophrenia has, at times, outpaced critical thinking and falsifiable hypotheses about the relative strengths vs. limitations of this measure. This review enumerates the realistic expectations for PPI in translational models for schizophrenia research, and provides cautionary notes for the future applications of this important research tool. In humans, PPI is not “diagnostic”; levels of PPI do not predict clinical course, specific symptoms, or individual medication responses. In preclinical studies, PPI is valuable for evaluating models or model organisms relevant to schizophrenia, “mapping” neural substrates of deficient PPI in schizophrenia, and advancing the discovery and development of novel therapeutics. Across species, PPI is a reliable, robust quantitative phenotype that is useful for probing the neurobiology and genetics of gating deficits in schizophrenia." @default.
- W2062472783 created "2016-06-24" @default.
- W2062472783 creator A5012580642 @default.
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- W2062472783 creator A5040060805 @default.
- W2062472783 creator A5042483033 @default.
- W2062472783 creator A5055966464 @default.
- W2062472783 date "2008-06-21" @default.
- W2062472783 modified "2023-10-03" @default.
- W2062472783 title "Realistic expectations of prepulse inhibition in translational models for schizophrenia research" @default.
- W2062472783 cites W1505441000 @default.
- W2062472783 cites W1529941862 @default.
- W2062472783 cites W1545972494 @default.
- W2062472783 cites W1549566968 @default.
- W2062472783 cites W1566594410 @default.
- W2062472783 cites W1569624083 @default.
- W2062472783 cites W1600469961 @default.
- W2062472783 cites W1605141488 @default.
- W2062472783 cites W1757694062 @default.
- W2062472783 cites W1919779618 @default.
- W2062472783 cites W1963956528 @default.
- W2062472783 cites W1963998256 @default.
- W2062472783 cites W1964763649 @default.
- W2062472783 cites W1965118964 @default.
- W2062472783 cites W1965368090 @default.
- W2062472783 cites W1965632303 @default.
- W2062472783 cites W1966080862 @default.
- W2062472783 cites W1966230851 @default.
- W2062472783 cites W1966525193 @default.
- W2062472783 cites W1966837018 @default.
- W2062472783 cites W1967089702 @default.
- W2062472783 cites W1967158391 @default.
- W2062472783 cites W1967590357 @default.
- W2062472783 cites W1968524760 @default.
- W2062472783 cites W1970290009 @default.
- W2062472783 cites W1970405593 @default.
- W2062472783 cites W1970507582 @default.
- W2062472783 cites W1970626803 @default.
- W2062472783 cites W1970806342 @default.
- W2062472783 cites W1971084704 @default.
- W2062472783 cites W1971815345 @default.
- W2062472783 cites W1971956255 @default.
- W2062472783 cites W1972616159 @default.
- W2062472783 cites W1972887428 @default.
- W2062472783 cites W1973196477 @default.
- W2062472783 cites W1973571408 @default.
- W2062472783 cites W1973947372 @default.
- W2062472783 cites W1974071870 @default.
- W2062472783 cites W1974559315 @default.
- W2062472783 cites W1974849634 @default.
- W2062472783 cites W1975052833 @default.
- W2062472783 cites W1975180862 @default.
- W2062472783 cites W1975187292 @default.
- W2062472783 cites W1975246577 @default.
- W2062472783 cites W1976117680 @default.
- W2062472783 cites W1976730655 @default.
- W2062472783 cites W1977039885 @default.
- W2062472783 cites W1978905259 @default.
- W2062472783 cites W1979001017 @default.
- W2062472783 cites W1979417746 @default.
- W2062472783 cites W1979733298 @default.
- W2062472783 cites W1980077228 @default.
- W2062472783 cites W1980320018 @default.
- W2062472783 cites W1980964198 @default.
- W2062472783 cites W1981706572 @default.
- W2062472783 cites W1981789373 @default.
- W2062472783 cites W1982144267 @default.
- W2062472783 cites W1982283113 @default.
- W2062472783 cites W1983545035 @default.
- W2062472783 cites W1983773888 @default.
- W2062472783 cites W1984003107 @default.
- W2062472783 cites W1984280194 @default.
- W2062472783 cites W1984304181 @default.
- W2062472783 cites W1984305433 @default.
- W2062472783 cites W1984355858 @default.
- W2062472783 cites W1984721650 @default.
- W2062472783 cites W1985196201 @default.
- W2062472783 cites W1985254321 @default.
- W2062472783 cites W1985407234 @default.
- W2062472783 cites W1985916296 @default.
- W2062472783 cites W1986615661 @default.
- W2062472783 cites W1986812115 @default.
- W2062472783 cites W1986858683 @default.
- W2062472783 cites W1986944898 @default.
- W2062472783 cites W1988144047 @default.
- W2062472783 cites W1988864968 @default.
- W2062472783 cites W1989161195 @default.
- W2062472783 cites W1989597801 @default.
- W2062472783 cites W1989720065 @default.
- W2062472783 cites W1990312367 @default.
- W2062472783 cites W1990458727 @default.
- W2062472783 cites W1990471091 @default.
- W2062472783 cites W1991897531 @default.
- W2062472783 cites W1993113552 @default.
- W2062472783 cites W1993136366 @default.
- W2062472783 cites W1993266955 @default.
- W2062472783 cites W1993644687 @default.
- W2062472783 cites W1995348909 @default.