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- W2062476872 abstract "Diabetic retinopathy (DR) is the most widespread complication of diabetes mellitus and a major cause of blindness in the working population of developed countries. The clinicopathology of the diabetic retina has been extensively studied, although the relative contribution of the various biochemical and molecular sequelae of hyperglycemia remains ill defined. Many neural and microvascular abnormalities occur in the retina of short-term diabetic animals but it remains uncertain how closely these acute changes relate to chronic human disease. It is important to determine the relationship between alterations observed within the first weeks or months in short-term animal models, and human disease, where clinically manifest retinopathy occurs only after durations of diabetes measured in years. This review is focused on the retinal microvasculature, although it should be appreciated that pathological changes in this system often occur in parallel with abnormalities in the neural parenchyma that may be derivative or even causal. Nevertheless, it is useful to reevaluate the microvascular lesions that are manifest in the retina during diabetes in humans and long-term animal models, since in addition to providing useful clues to the pathogenic basis of DR as a disease entity, it is in the deterrence of such changes that the efficacy of any novel treatment regimes will be measured. In particular, an emphasis will be placed on the relatively unappreciated role of arteriolar dysfunction in the clinical manifestations and pathology of this disease." @default.
- W2062476872 created "2016-06-24" @default.
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- W2062476872 creator A5016325390 @default.
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- W2062476872 date "2007-01-01" @default.
- W2062476872 modified "2023-10-14" @default.
- W2062476872 title "Arteriolar Involvement in the Microvascular Lesions of Diabetic Retinopathy: Implications for Pathogenesis" @default.
- W2062476872 cites W1262594188 @default.
- W2062476872 cites W133860319 @default.
- W2062476872 cites W180390437 @default.
- W2062476872 cites W188128768 @default.
- W2062476872 cites W1964144830 @default.
- W2062476872 cites W1965970213 @default.
- W2062476872 cites W1966941545 @default.
- W2062476872 cites W1967959200 @default.
- W2062476872 cites W1968111901 @default.
- W2062476872 cites W1968625953 @default.
- W2062476872 cites W1968649551 @default.
- W2062476872 cites W1969256358 @default.
- W2062476872 cites W1971853219 @default.
- W2062476872 cites W1975145708 @default.
- W2062476872 cites W1980131509 @default.
- W2062476872 cites W1980300611 @default.
- W2062476872 cites W1990644905 @default.
- W2062476872 cites W1992352481 @default.
- W2062476872 cites W1992968447 @default.
- W2062476872 cites W1993419164 @default.
- W2062476872 cites W1994778563 @default.
- W2062476872 cites W1995481203 @default.
- W2062476872 cites W2002940556 @default.
- W2062476872 cites W2005497411 @default.
- W2062476872 cites W2006241828 @default.
- W2062476872 cites W2006477603 @default.
- W2062476872 cites W2009673528 @default.
- W2062476872 cites W2011500110 @default.
- W2062476872 cites W2011915481 @default.
- W2062476872 cites W2018356945 @default.
- W2062476872 cites W2020059245 @default.
- W2062476872 cites W2023739408 @default.
- W2062476872 cites W2024522181 @default.
- W2062476872 cites W2025035446 @default.
- W2062476872 cites W2025837378 @default.
- W2062476872 cites W2034454591 @default.
- W2062476872 cites W2035721173 @default.
- W2062476872 cites W2039058126 @default.
- W2062476872 cites W2040965438 @default.
- W2062476872 cites W2041455832 @default.
- W2062476872 cites W2043389111 @default.
- W2062476872 cites W2043875133 @default.
- W2062476872 cites W2045777663 @default.
- W2062476872 cites W2045932444 @default.
- W2062476872 cites W2047330128 @default.
- W2062476872 cites W2048006500 @default.
- W2062476872 cites W2049476096 @default.
- W2062476872 cites W2053221174 @default.
- W2062476872 cites W2055188605 @default.
- W2062476872 cites W2055408595 @default.
- W2062476872 cites W2057683168 @default.
- W2062476872 cites W2060453818 @default.
- W2062476872 cites W2068203209 @default.
- W2062476872 cites W2071493554 @default.
- W2062476872 cites W2073130171 @default.
- W2062476872 cites W2074306198 @default.
- W2062476872 cites W2076017857 @default.
- W2062476872 cites W2079683065 @default.
- W2062476872 cites W2079792463 @default.
- W2062476872 cites W2084274661 @default.
- W2062476872 cites W2085647501 @default.
- W2062476872 cites W2086204342 @default.
- W2062476872 cites W2089958802 @default.
- W2062476872 cites W2106271145 @default.
- W2062476872 cites W2106527155 @default.
- W2062476872 cites W2109048773 @default.
- W2062476872 cites W2109257049 @default.
- W2062476872 cites W2111609408 @default.
- W2062476872 cites W2114283061 @default.
- W2062476872 cites W2114834794 @default.
- W2062476872 cites W2115390024 @default.
- W2062476872 cites W2119409817 @default.
- W2062476872 cites W2121679336 @default.
- W2062476872 cites W2122109377 @default.
- W2062476872 cites W2123638779 @default.
- W2062476872 cites W2128535483 @default.
- W2062476872 cites W2131393213 @default.
- W2062476872 cites W2134876590 @default.
- W2062476872 cites W2136815910 @default.
- W2062476872 cites W2141648382 @default.
- W2062476872 cites W2152557315 @default.
- W2062476872 cites W2153008086 @default.
- W2062476872 cites W2155061358 @default.
- W2062476872 cites W2156492806 @default.
- W2062476872 cites W2156590829 @default.
- W2062476872 cites W2163770614 @default.
- W2062476872 cites W2169926171 @default.
- W2062476872 cites W2171480988 @default.
- W2062476872 cites W2171651020 @default.