Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062489136> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2062489136 abstract "Purpose: The radiationdosedelivered from volumetric imaging guidance is normally between 1–10 cGy, depending on the imaging modalities, tumor sites and patient thickness. To correctly compensate for such doses, their biological effects on tumor and endothelial cells are investigated. Methods and materials: A lungcarcinomacell line (H460), a breast cancercell line (MCF‐7) and a prostate cancercell line (PC3) and a human umbilical vein endothelial cell line (HUVEC) were studied for their responses to small doses of radiation ranging from 5 cGy to 50 cGy. Specifically, a MTT assay was used to quantify their proliferation over time. To measure the impact of image guidance doses on cell survival, 5 cGy or 10 cGy were delivered to H460 cells before a 200 cGy therapeuticdose. The tumorcell survival was measured by clonogenic assay and compared with cells that received 200 cGy only. Results: Accelerated proliferation was observed among all tumorcell lines but not the HUVEC to low dose irradiation. The acceleration was statistically significant (p<0.05) for H460 and MFC7 cells but not for the PC3 cells. A 12.6% increase in the H460 cell survival was observed for cells receiving 5cGy before 200 cGy radiation compared to those that received 200 cGy alone (p<0.02), while cells receiving 10 cGy prior to 200 cGy had the same survival as cells receiving 200 cGy alone. Conclusions: Small pre‐treatment doses of radiation may increase the radioresistance of tumorcells. In this study, we demonstrated that the imagingdose from image guided radiation therapy is sufficient to trigger accelerated proliferation when delivered alone and increased tumor survival when delivered prior to a therapeuticdose. Our results suggest that subtracting the imagingdose from the therapeuticdose may adversely affect the tumor control probability." @default.
- W2062489136 created "2016-06-24" @default.
- W2062489136 creator A5001235172 @default.
- W2062489136 creator A5025195325 @default.
- W2062489136 creator A5032586506 @default.
- W2062489136 creator A5039815268 @default.
- W2062489136 creator A5056932023 @default.
- W2062489136 date "2009-06-01" @default.
- W2062489136 modified "2023-09-22" @default.
- W2062489136 title "TH-D-BRD-04: Increased Tumor Radioresistance by Imaging Doses From Volumetric Image Guided Radiation Therapy" @default.
- W2062489136 doi "https://doi.org/10.1118/1.3182658" @default.
- W2062489136 hasPublicationYear "2009" @default.
- W2062489136 type Work @default.
- W2062489136 sameAs 2062489136 @default.
- W2062489136 citedByCount "1" @default.
- W2062489136 countsByYear W20624891362015 @default.
- W2062489136 crossrefType "journal-article" @default.
- W2062489136 hasAuthorship W2062489136A5001235172 @default.
- W2062489136 hasAuthorship W2062489136A5025195325 @default.
- W2062489136 hasAuthorship W2062489136A5032586506 @default.
- W2062489136 hasAuthorship W2062489136A5039815268 @default.
- W2062489136 hasAuthorship W2062489136A5056932023 @default.
- W2062489136 hasConcept C117262875 @default.
- W2062489136 hasConcept C125118446 @default.
- W2062489136 hasConcept C126838900 @default.
- W2062489136 hasConcept C142724271 @default.
- W2062489136 hasConcept C2989005 @default.
- W2062489136 hasConcept C509974204 @default.
- W2062489136 hasConcept C54355233 @default.
- W2062489136 hasConcept C58962609 @default.
- W2062489136 hasConcept C71924100 @default.
- W2062489136 hasConcept C81885089 @default.
- W2062489136 hasConcept C86803240 @default.
- W2062489136 hasConceptScore W2062489136C117262875 @default.
- W2062489136 hasConceptScore W2062489136C125118446 @default.
- W2062489136 hasConceptScore W2062489136C126838900 @default.
- W2062489136 hasConceptScore W2062489136C142724271 @default.
- W2062489136 hasConceptScore W2062489136C2989005 @default.
- W2062489136 hasConceptScore W2062489136C509974204 @default.
- W2062489136 hasConceptScore W2062489136C54355233 @default.
- W2062489136 hasConceptScore W2062489136C58962609 @default.
- W2062489136 hasConceptScore W2062489136C71924100 @default.
- W2062489136 hasConceptScore W2062489136C81885089 @default.
- W2062489136 hasConceptScore W2062489136C86803240 @default.
- W2062489136 hasLocation W20624891361 @default.
- W2062489136 hasOpenAccess W2062489136 @default.
- W2062489136 hasPrimaryLocation W20624891361 @default.
- W2062489136 hasRelatedWork W1123802232 @default.
- W2062489136 hasRelatedWork W1973815768 @default.
- W2062489136 hasRelatedWork W1996707281 @default.
- W2062489136 hasRelatedWork W2010357749 @default.
- W2062489136 hasRelatedWork W2040272758 @default.
- W2062489136 hasRelatedWork W2042142774 @default.
- W2062489136 hasRelatedWork W2043107207 @default.
- W2062489136 hasRelatedWork W2047186824 @default.
- W2062489136 hasRelatedWork W2048452867 @default.
- W2062489136 hasRelatedWork W2056931194 @default.
- W2062489136 hasRelatedWork W2059491841 @default.
- W2062489136 hasRelatedWork W2063724677 @default.
- W2062489136 hasRelatedWork W2086562315 @default.
- W2062489136 hasRelatedWork W2099223140 @default.
- W2062489136 hasRelatedWork W2135176937 @default.
- W2062489136 hasRelatedWork W2141240569 @default.
- W2062489136 hasRelatedWork W2156072473 @default.
- W2062489136 hasRelatedWork W2369454098 @default.
- W2062489136 hasRelatedWork W2517538468 @default.
- W2062489136 hasRelatedWork W2914309046 @default.
- W2062489136 isParatext "false" @default.
- W2062489136 isRetracted "false" @default.
- W2062489136 magId "2062489136" @default.
- W2062489136 workType "article" @default.