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- W2062495890 abstract "The effects of exogenous GM1 ganglioside (GM1) on neurotoxininduced damage of cerebral serotonin (5-HT) nerve terminals in adult rats were studied with neurochemical and immunocytochemical techniques. 2 mM 5, 7-dihydroxytryptamine (5, 7-HT) was infused, intracortically, via an osmotic minipump for 7 days. Significant decreases in 5-HT and 5-hydroxy-indole 3-acetic acid (5-HIAA) levels and in the number of 5-HT nerve terminals were found in restricted areas around the infusion points. Treatment with GM1 (20 mg/kg, i. p., daily) for 3 days before the 5, 7-HT infusion and for another 7-14 days after 5, 7 -HT infusion significantly enhanced 5-HT recovery, 5-HIAA recovery, the number of the nerve terminals at the infusion points, and 5-HIAA recovery in areas caudal to the infusion points. GM1 had no inhibitory effects on the 5, 7-HT-induced 5-HT depletion acutely, indicating that GM1 does not suppress the direct neurotoxic actions of 5, 7-HT. These results indicate that the effect of GM1 may be related to a stimulatory effect on regrowth and/or to a protective action against degeneration of 5-HT axons following the initial 5, 7-HT induced lesion of the 5-HT nerve terminals." @default.
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- W2062495890 date "1988-01-01" @default.
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- W2062495890 title "The effects of exogenous GM1 ganglioside on neurotoxin induced damage of cerebral serotonin nerve terminals in adult rats." @default.
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- W2062495890 doi "https://doi.org/10.2739/kurumemedj.35.49" @default.
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