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• W2062505071 startingPage "e32777" @default.
• W2062505071 abstract "Background Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK) – Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other biological systems. To gain further insight into immune system evolution, we have performed a comprehensive bioinformatic analysis of the JAK-STAT pathway components, including the key negative regulators of this pathway, the SH2-domain containing tyrosine phosphatase (SHP), Protein inhibitors against Stats (PIAS), and Suppressor of cytokine signaling (SOCS) proteins across a diverse range of organisms. Results Our analysis has demonstrated significant expansion of JAK-STAT pathway components co-incident with the emergence of adaptive immunity, with whole genome duplication being the principal mechanism for generating this additional diversity. In contrast, expansion of upstream cytokine receptors appears to be a pivotal driver for the differential diversification of specific pathway components. Conclusion Diversification of JAK-STAT pathway components during early vertebrate development occurred concurrently with a major expansion of upstream cytokine receptors and two rounds of whole genome duplications. This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity." @default.
• W2062505071 created "2016-06-24" @default.
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• W2062505071 creator A5017906784 @default.
• W2062505071 creator A5031821646 @default.
• W2062505071 creator A5067625841 @default.
• W2062505071 date "2012-03-07" @default.
• W2062505071 modified "2023-10-18" @default.
• W2062505071 title "Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development" @default.
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• W2062505071 doi "https://doi.org/10.1371/journal.pone.0032777" @default.
• W2062505071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3296744" @default.
• W2062505071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22412924" @default.
• W2062505071 hasPublicationYear "2012" @default.
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