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• W2062509589 abstract "<i>Objective:</i> To study the effects of <i>Tamarindus indica</i> L. aqueous fruit extract on the antinociceptive activities in rodent models. <i>Methods:</i> The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. <i>Results:</i> The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. <i>Conclusion:</i> The aqueous extract of <i>T. indica</i> possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism." @default.
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• W2062509589 date "2010-01-01" @default.
• W2062509589 modified "2023-10-01" @default.
• W2062509589 title "In vivo Analgesic Effect of Aqueous Extract of <i>Tamarindus indica</i> L. Fruits" @default.
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• W2062509589 doi "https://doi.org/10.1159/000312710" @default.
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