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- W2062510183 abstract "The structure-toxicity relationship of monoketones was examined in mice. In all test compounds, the acute oral toxicity (LD50) was determined under two conditions; control LD50 (LD50-cont.) and carbon tetrachloride (CCl4)-pretreated LD50 (LD50CCl4). LD50-cont. was larger than LD50-CCl4 in all test compounds, the difference being greater in compounds with longer carbon chains than in those with shorter chains. Both LD50-cont. and LD50-CCl4 were parabolic functions of the partition coefficient, log P, i.e., log (1/LD50-cont.) = -0.120(log P)2 + 0.417log P - 1.734 and log(1/LD50-CCl4) = -0.103(log P)2 + 0.462log P - 1.660, and both equations were statistically significant (P less than 0.01). The log Po values were 1.74 for the former and 2.24 for the latter." @default.
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- W2062510183 date "1986-01-01" @default.
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- W2062510183 title "Structure-toxicity relationship of monoketones" @default.
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- W2062510183 doi "https://doi.org/10.1016/0378-4274(86)90173-6" @default.
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