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- W2062521477 abstract "The prevalence of tardive dyskinesia (TD) in chronic psychiatric outpatients was significantly higher in smokers (46/85) than in nonsmokers (18/69) (p less than 0.001). This increased prevalence was associated with a significantly greater prescribed dose of neuroleptics in women, but not in men. Nicotine increases the synthesis and release of dopamine in the nigrostriatal pathway of animals. Such a mechanism may contribute to the higher prevalence of TD in smokers. The present findings suggest that smoking is a risk factor for the development of TD. A statistically significant association between smoking and TD, however, does not necessarily imply a cause-effect relationship. Treatment of TD with mecamylamine or other central nicotine antagonists merits investigation." @default.
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- W2062521477 date "1987-01-01" @default.
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- W2062521477 title "Nicotine exposure and tardive dyskinesia" @default.
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- W2062521477 doi "https://doi.org/10.1016/0006-3223(87)90131-4" @default.
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