Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062530515> ?p ?o ?g. }
- W2062530515 abstract "Abstract Fasciola hepatica is a liver fluke that infects 2.4 million of people and causes great economical loss in animal production. To date a 100% effective vaccine has not been developed and the disease is controlled by drug therapy. Great efforts are put into development of effective vaccine against parasite what is difficult since Fasciola spp. (like other helmints) during evolutionary process has developed sophisticated and efficient methods to evade immune response. During preliminary experiments it is convenient to use cell lines which are relatively cheap and allow for reproducible comparison of results between laboratories. We stimulated BOMA (bovine monocyte/macrophage cell line) and BOMAC (bovine macrophage cell line) with native or recombinant antigens of Fasciola hepatica and assessed IFN-γ, IL-4 and TNF-α level upon stimulation. We observed diminished secretion of proinflammatory TNF-α in LPS activated BOMA cells stimulated with Excretory/Secretory products of adult fluke (Fh-ES). We also observed greater changes in gene expression in LPS activated BOMA cells than in non activated BOMA cells upon stimulation using Fh-ES. The results show possibility of using cell lines for in vitro research of bovine immune response against liver fluke, although this model still requires validation and further characterization." @default.
- W2062530515 created "2016-06-24" @default.
- W2062530515 creator A5007448315 @default.
- W2062530515 creator A5007844491 @default.
- W2062530515 creator A5014660986 @default.
- W2062530515 creator A5036252272 @default.
- W2062530515 creator A5045487353 @default.
- W2062530515 creator A5060197332 @default.
- W2062530515 creator A5072903742 @default.
- W2062530515 creator A5083533339 @default.
- W2062530515 creator A5087814315 @default.
- W2062530515 date "2013-01-01" @default.
- W2062530515 modified "2023-10-14" @default.
- W2062530515 title "Fasciola hepatica — the pilot study of in vitro assessing immune response against native and recombinant antigens of the fluke" @default.
- W2062530515 cites W1972528301 @default.
- W2062530515 cites W1985770788 @default.
- W2062530515 cites W1987646859 @default.
- W2062530515 cites W1993583532 @default.
- W2062530515 cites W2009439501 @default.
- W2062530515 cites W2046351079 @default.
- W2062530515 cites W2054188983 @default.
- W2062530515 cites W2072150717 @default.
- W2062530515 cites W2094998346 @default.
- W2062530515 cites W2096244860 @default.
- W2062530515 cites W2116424088 @default.
- W2062530515 cites W2130846425 @default.
- W2062530515 cites W2131678280 @default.
- W2062530515 cites W2134637346 @default.
- W2062530515 cites W2139053894 @default.
- W2062530515 cites W2139137351 @default.
- W2062530515 cites W2144677044 @default.
- W2062530515 cites W2149885988 @default.
- W2062530515 cites W2159923852 @default.
- W2062530515 cites W2162870507 @default.
- W2062530515 doi "https://doi.org/10.2478/s11686-013-0163-5" @default.
- W2062530515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24338305" @default.
- W2062530515 hasPublicationYear "2013" @default.
- W2062530515 type Work @default.
- W2062530515 sameAs 2062530515 @default.
- W2062530515 citedByCount "14" @default.
- W2062530515 countsByYear W20625305152015 @default.
- W2062530515 countsByYear W20625305152016 @default.
- W2062530515 countsByYear W20625305152017 @default.
- W2062530515 countsByYear W20625305152019 @default.
- W2062530515 countsByYear W20625305152022 @default.
- W2062530515 countsByYear W20625305152023 @default.
- W2062530515 crossrefType "journal-article" @default.
- W2062530515 hasAuthorship W2062530515A5007448315 @default.
- W2062530515 hasAuthorship W2062530515A5007844491 @default.
- W2062530515 hasAuthorship W2062530515A5014660986 @default.
- W2062530515 hasAuthorship W2062530515A5036252272 @default.
- W2062530515 hasAuthorship W2062530515A5045487353 @default.
- W2062530515 hasAuthorship W2062530515A5060197332 @default.
- W2062530515 hasAuthorship W2062530515A5072903742 @default.
- W2062530515 hasAuthorship W2062530515A5083533339 @default.
- W2062530515 hasAuthorship W2062530515A5087814315 @default.
- W2062530515 hasBestOaLocation W20625305151 @default.
- W2062530515 hasConcept C13590703 @default.
- W2062530515 hasConcept C147483822 @default.
- W2062530515 hasConcept C159047783 @default.
- W2062530515 hasConcept C165901193 @default.
- W2062530515 hasConcept C202751555 @default.
- W2062530515 hasConcept C203014093 @default.
- W2062530515 hasConcept C2777228834 @default.
- W2062530515 hasConcept C2777856171 @default.
- W2062530515 hasConcept C2779244956 @default.
- W2062530515 hasConcept C55493867 @default.
- W2062530515 hasConcept C86803240 @default.
- W2062530515 hasConcept C8891405 @default.
- W2062530515 hasConceptScore W2062530515C13590703 @default.
- W2062530515 hasConceptScore W2062530515C147483822 @default.
- W2062530515 hasConceptScore W2062530515C159047783 @default.
- W2062530515 hasConceptScore W2062530515C165901193 @default.
- W2062530515 hasConceptScore W2062530515C202751555 @default.
- W2062530515 hasConceptScore W2062530515C203014093 @default.
- W2062530515 hasConceptScore W2062530515C2777228834 @default.
- W2062530515 hasConceptScore W2062530515C2777856171 @default.
- W2062530515 hasConceptScore W2062530515C2779244956 @default.
- W2062530515 hasConceptScore W2062530515C55493867 @default.
- W2062530515 hasConceptScore W2062530515C86803240 @default.
- W2062530515 hasConceptScore W2062530515C8891405 @default.
- W2062530515 hasIssue "4" @default.
- W2062530515 hasLocation W20625305151 @default.
- W2062530515 hasLocation W20625305152 @default.
- W2062530515 hasOpenAccess W2062530515 @default.
- W2062530515 hasPrimaryLocation W20625305151 @default.
- W2062530515 hasRelatedWork W1130780380 @default.
- W2062530515 hasRelatedWork W1987098760 @default.
- W2062530515 hasRelatedWork W2090737829 @default.
- W2062530515 hasRelatedWork W2131991032 @default.
- W2062530515 hasRelatedWork W2238083955 @default.
- W2062530515 hasRelatedWork W2330920752 @default.
- W2062530515 hasRelatedWork W2420158158 @default.
- W2062530515 hasRelatedWork W2460767104 @default.
- W2062530515 hasRelatedWork W2993374719 @default.
- W2062530515 hasRelatedWork W3025347557 @default.
- W2062530515 hasVolume "58" @default.
- W2062530515 isParatext "false" @default.
- W2062530515 isRetracted "false" @default.
- W2062530515 magId "2062530515" @default.