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- W2062553517 abstract "Polycystic ovary syndrome (PCOS) is manifested by hyperandrogenism that is commonly associated with insulin resistance, hyperinsulinemia,7, 14, 22 obesity,22, 23 hypertension, and dyslipidemia.22, 66, 81, 98 PCOS entails a substantially increased incidence of type 2 diabetes mellitus in midadult life and an increased risk for cardiovascular disease. The incidence of PCOS is approximately 5% to 10%, making it of the most common endocrinopathies in women of reproductive age.26 Prominent manifestations include hyperandrogenism and altered gonadotropin secretion, anovulation, infertility, heavy and unpredictable menstrual bleeding, hirsutism, alopecia, acne, and obesity.26 Typically, abnormalities include elevated plasma concentrations of luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-S), testosterone, and insulin, and diminished concentrations of sex hormone–binding globulin (SHBG) and follicle-stimulating hormone. Diagnosis requires recognition of the hormonal abnormalities, with the exclusion of nonclassic adrenal 21-hydroxylase deficiency and androgen-secreting neoplasms. PCOS may be associated with polycystic changes in the ovaries, although these are not essential for diagnosis. Macrovascular coronary artery disease is a major risk in PCOS. A fourfold increase in the relative risk of myocardial infarction in postmenopausal women with a history of ovarian wedge resection for PCOS at age 40 to 49 years and an 11-fold increase at age 50 to 60 years was found in a retrospective study.18 The increased risk may be attributable, in part, to insulin resistance for many years with or without subsequent overt type II diabetes, obesity, hyperlipidemia, hypertension, hyperandrogenism, and impaired fibrinolysis." @default.
- W2062553517 created "2016-06-24" @default.
- W2062553517 creator A5035615314 @default.
- W2062553517 creator A5050166855 @default.
- W2062553517 date "1999-06-01" @default.
- W2062553517 modified "2023-10-10" @default.
- W2062553517 title "CARDIOVASCULAR CONSEQUENCES OF POLYCYSTIC OVARY SYNDROME" @default.
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- W2062553517 doi "https://doi.org/10.1016/s0889-8529(05)70079-7" @default.
- W2062553517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10352928" @default.
- W2062553517 hasPublicationYear "1999" @default.