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• W2062556485 abstract "Three compounds were isolated from Acnistus arborescens, a tree commonly used in South and Central America in traditional medicine against several infectious diseases, some of which are caused by fungi. Bioassay-guided fractionation of a MeOH extract of leaves, based on its anti-Pneumocystis carinii activity, led to the isolation of compounds 1-3. Mono- and bidimensional NMR analyses enabled identification of two new withanolides, (20R,22R)-5beta,6beta-epoxy-4beta,12beta,20-trihydroxy-1-oxowith-2-en-24-enolide (1) and (20R,22R)-16beta-acetoxy-3beta,4beta;5beta,6beta-diepoxy-12beta,20-dihydroxy-1-oxowith-24-enolide (2), and withanolide D (3). Antifungal activity on 13 fungi responsible for human infections (five dermatophytes, one nondermatophyte mold, six yeasts, and Pneumocystis carinii) was examined. Cytotoxicity of these compounds was also evaluated in vitro." @default.
• W2062556485 created "2016-06-24" @default.
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• W2062556485 date "2010-06-30" @default.
• W2062556485 modified "2023-10-06" @default.
• W2062556485 title "Antifungal and Cytotoxic Activity of Withanolides from <i>Acnistus arborescens</i>" @default.
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• W2062556485 doi "https://doi.org/10.1021/np100201p" @default.
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