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- W2062558677 abstract "Abstract We report the identification, cloning, heterologous expression and functional characterization of a novel antifungal peptide named lucimycin from the common green bottle fly Lucilia sericata . The lucimycin cDNA was isolated from a library of genes induced during the innate immune response in L. sericata larvae, which are used as therapeutic maggots. The peptide comprises 77 amino acid residues with a molecular mass of 8.2 kDa and a p I of 6.6. It is predicted to contain a zinc-binding motif and to form a random coil, lacking β-sheets or other secondary structures. Lucimycin was active against fungi from the phyla Ascomycota, Basidiomycota and Zygomycota, in addition to the oomycete Phytophtora parasitica , but it was inactive against bacteria. A mutant version of lucimycin, lacking the four C-terminal amino acid residues, displayed 40-fold lower activity. The activity of lucimycin against a number of highly-destructive plant pathogens could be exploited to produce transgenic crops that are resistant against fungal diseases." @default.
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- W2062558677 date "2014-03-12" @default.
- W2062558677 modified "2023-10-17" @default.
- W2062558677 title "Lucimycin, an antifungal peptide from the therapeutic maggot of the common green bottle fly <i>Lucilia sericata</i>" @default.
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- W2062558677 doi "https://doi.org/10.1515/hsz-2013-0263" @default.
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