Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062570792> ?p ?o ?g. }
- W2062570792 endingPage "e1002080" @default.
- W2062570792 startingPage "e1002080" @default.
- W2062570792 abstract "Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue. During transmission of malaria, parasite motility in the skin is important for Plasmodium sporozoites to reach the blood circulation. Here we show that sporozoite migration varies in different skin environments the parasite encounters at the arbitrary sites of the mosquito bite. In order to systematically examine how sporozoite migration depends on the structure of the environment, we studied it in micro-fabricated obstacle arrays. The trajectories observed in vivo and in vitro closely resemble each other suggesting that structural constraints can be sufficient to guide Plasmodium sporozoites in complex environments. Sporozoite speed in different environments is optimized for migration and correlates with persistence length and dispersal. However, this correlation breaks down in mutant sporozoites that show adhesion impairment due to the lack of TRAP-like protein (TLP) on their surfaces. This may explain their delay in infecting the host. The flexibility of sporozoite adaption to different environments and a favorable speed for optimal dispersal ensures efficient host switching during malaria transmission." @default.
- W2062570792 created "2016-06-24" @default.
- W2062570792 creator A5000422418 @default.
- W2062570792 creator A5000918141 @default.
- W2062570792 creator A5002312805 @default.
- W2062570792 creator A5013037530 @default.
- W2062570792 creator A5016638746 @default.
- W2062570792 creator A5039296218 @default.
- W2062570792 creator A5045245243 @default.
- W2062570792 creator A5071704167 @default.
- W2062570792 creator A5084331886 @default.
- W2062570792 creator A5088059960 @default.
- W2062570792 date "2011-06-16" @default.
- W2062570792 modified "2023-10-01" @default.
- W2062570792 title "Environmental Constraints Guide Migration of Malaria Parasites during Transmission" @default.
- W2062570792 cites W1905994259 @default.
- W2062570792 cites W1969054982 @default.
- W2062570792 cites W1973529656 @default.
- W2062570792 cites W1980463883 @default.
- W2062570792 cites W1993356393 @default.
- W2062570792 cites W1993795323 @default.
- W2062570792 cites W1997412782 @default.
- W2062570792 cites W1997681499 @default.
- W2062570792 cites W2002478108 @default.
- W2062570792 cites W2007759522 @default.
- W2062570792 cites W2014714640 @default.
- W2062570792 cites W2015621465 @default.
- W2062570792 cites W2026109859 @default.
- W2062570792 cites W2029131750 @default.
- W2062570792 cites W2036129024 @default.
- W2062570792 cites W2036256399 @default.
- W2062570792 cites W2039132575 @default.
- W2062570792 cites W2040611232 @default.
- W2062570792 cites W2045571578 @default.
- W2062570792 cites W2047798716 @default.
- W2062570792 cites W2048080607 @default.
- W2062570792 cites W2055047552 @default.
- W2062570792 cites W2060403328 @default.
- W2062570792 cites W2060650331 @default.
- W2062570792 cites W2062478481 @default.
- W2062570792 cites W2064864983 @default.
- W2062570792 cites W2071049632 @default.
- W2062570792 cites W2071979597 @default.
- W2062570792 cites W2087650666 @default.
- W2062570792 cites W2094725247 @default.
- W2062570792 cites W2099528288 @default.
- W2062570792 cites W2107885482 @default.
- W2062570792 cites W2110148884 @default.
- W2062570792 cites W2111104167 @default.
- W2062570792 cites W2111811045 @default.
- W2062570792 cites W2116575985 @default.
- W2062570792 cites W2122413738 @default.
- W2062570792 cites W2125753081 @default.
- W2062570792 cites W2144721986 @default.
- W2062570792 cites W2145287259 @default.
- W2062570792 cites W2149928606 @default.
- W2062570792 cites W2153106532 @default.
- W2062570792 cites W2156711536 @default.
- W2062570792 cites W2168908538 @default.
- W2062570792 doi "https://doi.org/10.1371/journal.ppat.1002080" @default.
- W2062570792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3116815" @default.
- W2062570792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21698220" @default.
- W2062570792 hasPublicationYear "2011" @default.
- W2062570792 type Work @default.
- W2062570792 sameAs 2062570792 @default.
- W2062570792 citedByCount "59" @default.
- W2062570792 countsByYear W20625707922012 @default.
- W2062570792 countsByYear W20625707922013 @default.
- W2062570792 countsByYear W20625707922014 @default.
- W2062570792 countsByYear W20625707922015 @default.
- W2062570792 countsByYear W20625707922016 @default.
- W2062570792 countsByYear W20625707922017 @default.
- W2062570792 countsByYear W20625707922018 @default.
- W2062570792 countsByYear W20625707922019 @default.
- W2062570792 countsByYear W20625707922020 @default.
- W2062570792 countsByYear W20625707922021 @default.
- W2062570792 countsByYear W20625707922022 @default.
- W2062570792 countsByYear W20625707922023 @default.
- W2062570792 crossrefType "journal-article" @default.
- W2062570792 hasAuthorship W2062570792A5000422418 @default.
- W2062570792 hasAuthorship W2062570792A5000918141 @default.
- W2062570792 hasAuthorship W2062570792A5002312805 @default.
- W2062570792 hasAuthorship W2062570792A5013037530 @default.
- W2062570792 hasAuthorship W2062570792A5016638746 @default.
- W2062570792 hasAuthorship W2062570792A5039296218 @default.
- W2062570792 hasAuthorship W2062570792A5045245243 @default.
- W2062570792 hasAuthorship W2062570792A5071704167 @default.
- W2062570792 hasAuthorship W2062570792A5084331886 @default.
- W2062570792 hasAuthorship W2062570792A5088059960 @default.
- W2062570792 hasBestOaLocation W20625707921 @default.
- W2062570792 hasConcept C126831891 @default.
- W2062570792 hasConcept C136764020 @default.
- W2062570792 hasConcept C144024400 @default.
- W2062570792 hasConcept C149923435 @default.
- W2062570792 hasConcept C170493617 @default.
- W2062570792 hasConcept C18903297 @default.
- W2062570792 hasConcept C203014093 @default.
- W2062570792 hasConcept C2778048844 @default.