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- W2062576070 abstract "This review discusses the role that the sperm-specific phospholipase C zeta (PLCζ) is proposed to play during the fertilization of mammalian eggs. At fertilization, the sperm initiates development by causing a series of oscillations in cytosolic concentrations of calcium [Ca2] within the egg. PLCζ mimics the sperm at fertilization, causing the same pattern of Ca2+ release as seen at fertilization. Introducing PLCζ into mouse eggs also mimics a number of other features of the way in which the fertilizing sperm triggers Ca2+ oscillations. We discuss the localization of PLCζ within the egg and present a hypothesis about the localization of PLCζ within the sperm before the initiation of fertilization." @default.
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- W2062576070 date "2014-08-01" @default.
- W2062576070 modified "2023-10-15" @default.
- W2062576070 title "Sperm-induced Ca2+ release during egg activation in mammals" @default.
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- W2062576070 doi "https://doi.org/10.1016/j.bbrc.2014.04.078" @default.
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