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- W2062580320 abstract "Significance of the formation of 4-dimethylamino-3-hydroxymethyl-2-methyl-1-phenyl-3-pyrazolin-5-on e (AM-3-CH2OH) for the metabolism of AM was examined quantitatively in rats. Although urinary excretion of AM-3-CH2OH accounted for only 0.7% to the dose, incubation of AM in the isolated hepatocyte system resulted in the formation of 9% of AM-3-CH2OH. Furthermore, metabolic disappearance of AM-3-CH2OH in the same system was fast, indicating the properties of an intermediate metabolite. These results suggested that the metabolic pathways via AM-3-CH2OH are very important in the metabolism of AM." @default.
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- W2062580320 date "1984-01-01" @default.
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- W2062580320 title "Biohydroxylation of aminopyrine: Quantitative studies of 3-hydroxymethyl metabolite in rats." @default.
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- W2062580320 doi "https://doi.org/10.1248/bpb1978.7.702" @default.
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