Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062586571> ?p ?o ?g. }
- W2062586571 endingPage "207" @default.
- W2062586571 startingPage "193" @default.
- W2062586571 abstract "Estrogen modulates the function of cholinergic basal forebrain neurons in aged female rats. The present study tested the hypothesis that estrogen enhances the phenotype of cholinergic basal forebrain neurons and their cortical cholinergic innervation in young adult and aged ovariectomized rhesus monkeys. Sixteen monkeys (9 young and 7 aged) received two injections of estradiol cypionate or vehicle separated by 3 weeks. All monkeys were killed 1 day after the last injection. Quantitative immunofluorescence in the vertical limb of the diagonal band (VLDB) revealed enhanced optical density for choline acetyltransferase (ChAT) in both young and aged monkeys treated with estrogen. In contrast, optical density for low-affinity p75 neurotrophin receptor immunoreactivity in the VLDB did not change after estrogen treatment in either aged or young animals. Quantitative immunofluorescence for either ChAT or the low-affinity p75 neurotrophin receptor in the nucleus basalis Meynert failed to reveal differences between vehicle and estrogen treatment in either age group. Quantitative estimates of acetylcholinesterase (AChE) fiber density revealed that estrogen-treated aged monkeys but not their younger counterparts had decreased numbers of AChE-positive fibers in layer II of frontal, insular, and cingulate cortices. These data indicate that estrogen administered in a manner simulating natural hormonal cyclicity produces modest age-specific chemical phenotypic and regional changes in select neuronal subfields of the cholinergic basal forebrain and their cortical projection sites in nonhuman primates." @default.
- W2062586571 created "2016-06-24" @default.
- W2062586571 creator A5009294785 @default.
- W2062586571 creator A5037061653 @default.
- W2062586571 creator A5045886993 @default.
- W2062586571 creator A5063461318 @default.
- W2062586571 creator A5068446591 @default.
- W2062586571 creator A5070294274 @default.
- W2062586571 creator A5072527270 @default.
- W2062586571 creator A5074765508 @default.
- W2062586571 creator A5077753619 @default.
- W2062586571 date "2004-01-01" @default.
- W2062586571 modified "2023-09-23" @default.
- W2062586571 title "Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys" @default.
- W2062586571 cites W1635991092 @default.
- W2062586571 cites W1930427841 @default.
- W2062586571 cites W1964606698 @default.
- W2062586571 cites W1964729801 @default.
- W2062586571 cites W1964882593 @default.
- W2062586571 cites W1969090164 @default.
- W2062586571 cites W1972153963 @default.
- W2062586571 cites W1973334224 @default.
- W2062586571 cites W1976426926 @default.
- W2062586571 cites W1977598790 @default.
- W2062586571 cites W1982708468 @default.
- W2062586571 cites W1988114656 @default.
- W2062586571 cites W1995051006 @default.
- W2062586571 cites W1998443184 @default.
- W2062586571 cites W2002297740 @default.
- W2062586571 cites W2004584009 @default.
- W2062586571 cites W2013854477 @default.
- W2062586571 cites W2017959247 @default.
- W2062586571 cites W2029193046 @default.
- W2062586571 cites W2031917138 @default.
- W2062586571 cites W2032679733 @default.
- W2062586571 cites W2034639126 @default.
- W2062586571 cites W2041018937 @default.
- W2062586571 cites W2042176328 @default.
- W2062586571 cites W2042812490 @default.
- W2062586571 cites W2044234384 @default.
- W2062586571 cites W2045525515 @default.
- W2062586571 cites W2047218252 @default.
- W2062586571 cites W2047693500 @default.
- W2062586571 cites W2048767002 @default.
- W2062586571 cites W2055090365 @default.
- W2062586571 cites W2055174017 @default.
- W2062586571 cites W2056371795 @default.
- W2062586571 cites W2058272963 @default.
- W2062586571 cites W2062706679 @default.
- W2062586571 cites W2063184348 @default.
- W2062586571 cites W2064365667 @default.
- W2062586571 cites W2070176134 @default.
- W2062586571 cites W2072538942 @default.
- W2062586571 cites W2075625163 @default.
- W2062586571 cites W2083042145 @default.
- W2062586571 cites W2083816457 @default.
- W2062586571 cites W2088514983 @default.
- W2062586571 cites W2089363694 @default.
- W2062586571 cites W2093377483 @default.
- W2062586571 cites W2100271408 @default.
- W2062586571 cites W2111727127 @default.
- W2062586571 cites W2121543539 @default.
- W2062586571 cites W2125643527 @default.
- W2062586571 cites W2128378551 @default.
- W2062586571 cites W2131266318 @default.
- W2062586571 cites W2131303835 @default.
- W2062586571 cites W2133052659 @default.
- W2062586571 cites W2135910109 @default.
- W2062586571 cites W2142276934 @default.
- W2062586571 cites W2146126584 @default.
- W2062586571 cites W2150771326 @default.
- W2062586571 cites W2151012090 @default.
- W2062586571 cites W2167318060 @default.
- W2062586571 cites W292304029 @default.
- W2062586571 cites W53200172 @default.
- W2062586571 doi "https://doi.org/10.1002/cne.20050" @default.
- W2062586571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15048687" @default.
- W2062586571 hasPublicationYear "2004" @default.
- W2062586571 type Work @default.
- W2062586571 sameAs 2062586571 @default.
- W2062586571 citedByCount "34" @default.
- W2062586571 countsByYear W20625865712013 @default.
- W2062586571 countsByYear W20625865712015 @default.
- W2062586571 countsByYear W20625865712016 @default.
- W2062586571 countsByYear W20625865712017 @default.
- W2062586571 crossrefType "journal-article" @default.
- W2062586571 hasAuthorship W2062586571A5009294785 @default.
- W2062586571 hasAuthorship W2062586571A5037061653 @default.
- W2062586571 hasAuthorship W2062586571A5045886993 @default.
- W2062586571 hasAuthorship W2062586571A5063461318 @default.
- W2062586571 hasAuthorship W2062586571A5068446591 @default.
- W2062586571 hasAuthorship W2062586571A5070294274 @default.
- W2062586571 hasAuthorship W2062586571A5072527270 @default.
- W2062586571 hasAuthorship W2062586571A5074765508 @default.
- W2062586571 hasAuthorship W2062586571A5077753619 @default.
- W2062586571 hasConcept C104966671 @default.
- W2062586571 hasConcept C121608353 @default.
- W2062586571 hasConcept C126322002 @default.