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• W2062601401 abstract "To establish the sequence of events leading from vitreofoveal traction to full-thickness macular hole formation.Both eyes of 76 patients with a full-thickness macular hole in at least 1 eye were examined by biomicroscopy and optical coherence tomography.Sixty-one fellow eyes had a normal macula. Optical coherence tomograms showed central detachment of the posterior hyaloid over the posterior pole in 19 cases (31%) and a perifoveal hyaloid detachment not detected on biomicroscopy in 26 cases (42%). In the 4 impending macular holes, optical coherence tomography disclosed various degrees of intrafoveal split or cyst, with adherence of the posterior hyaloid to the foveal center and convex perifoveal detachment. In the 14 stage 2 holes, eccentric opening of the roof of the hole was observed, and in the 24 stage 3 holes, the posterior hyaloid was detached from the entire posterior pole.In fellow eyes of eyes with macular holes posterior hyaloid detachment begins around the macula, but the hyaloid remains adherent to the foveolar center, indicating the action of anteroposterior forces. This results in an intraretinal split evolving into a cystic space, and then to the disruption of the outer retinal layer and the opening of the foveal floor, thus constituting a full-thickness macular hole." @default.
• W2062601401 created "2016-06-24" @default.
• W2062601401 creator A5031389649 @default.
• W2062601401 date "1999-06-01" @default.
• W2062601401 modified "2023-10-06" @default.
• W2062601401 title "Macular Hole Formation" @default.
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• W2062601401 doi "https://doi.org/10.1001/archopht.117.6.744" @default.
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