FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062630004> ?p ?o ?g. }

• W2062630004 endingPage "739" @default.
• W2062630004 startingPage "733" @default.
• W2062630004 abstract "We investigated whether polymorphisms in reduced folate carrier (SLC19A1 G80A) and γ-glutamyl-hydrolase (GGH–401C/T) are predictive of methotrexate polyglutamate (MTXPG) levels in patients with rheumatoid arthritis treated with weekly low-dose methotrexate (MTX). Adult patients treated with MTX were enrolled in a multicentred study. Blood was drawn at the time of the visit, DNA was extracted and red blood cell (RBC) MTXPG levels (up to the penta-order of glutamation) were measured by high-performance liquid chromatography-fluorometry. A G80A polymorphism in SLC19A1 and a −401C/T promoter polymorphism in GGH were measured by polymerase chain reaction-restriction fragment length polymorphism. Multivariate linear and logistic regressions were used to predict long-chain RBC MTXPG3–5. In 226 adult patients receiving MTX (median 15 mg range: 5–25 mg) median RBC long-chain MTXPG3–5 was 56 nmol/l (range < 5–224 nmol/l). A total of 35 patients carried the SLC19A1 80AA genotype whereas 36 patients carried the GGH–401TT genotype. Weekly MTX dose, age, presence of the SLC19A1 80AA and GGH–401TT genotypes predicted independently and significantly MTXPG3–5 levels (global r2 = 0.38; P< 0.0001). Patients with the GGH–401TT genotype were 4.8-fold [odds ratio (OR) 95% confidence interval (CI) 1.8–13.0; P = 0.002] more likely to have MTXPG3–5 below the group median compared to patient carriers of the GGH–401CC or CT genotype. Conversely, those with the SLC19A1 80AA genotype were 3.4-fold more likely to have MTXPG3–5 levels above the group median compared to those with the SLC19A1 80GG or 80GA genotype (OR CI 95% 1.4–8.4; P = 0.007). These data demonstrate that polymorphisms in SLC19A1 and GGH affect polyglutamation of MTX." @default.
• W2062630004 created "2016-06-24" @default.
• W2062630004 creator A5005428001 @default.
• W2062630004 creator A5014147030 @default.
• W2062630004 creator A5021773294 @default.
• W2062630004 creator A5039850816 @default.
• W2062630004 creator A5044844718 @default.
• W2062630004 creator A5059206584 @default.
• W2062630004 creator A5070979458 @default.
• W2062630004 creator A5073369495 @default.
• W2062630004 creator A5081600395 @default.
• W2062630004 date "2004-11-01" @default.
• W2062630004 modified "2023-10-01" @default.
• W2062630004 title "Contribution of common polymorphisms in reduced folate carrier and ??-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis" @default.
• W2062630004 cites W1489298252 @default.
• W2062630004 cites W1594621311 @default.
• W2062630004 cites W1596051841 @default.
• W2062630004 cites W1982767795 @default.
• W2062630004 cites W1983779362 @default.
• W2062630004 cites W2010650782 @default.
• W2062630004 cites W2019995269 @default.
• W2062630004 cites W2043804660 @default.
• W2062630004 cites W2047861739 @default.
• W2062630004 cites W2053006426 @default.
• W2062630004 cites W2053867192 @default.
• W2062630004 cites W2058471639 @default.
• W2062630004 cites W2069009549 @default.
• W2062630004 cites W2070009272 @default.
• W2062630004 cites W2070822335 @default.
• W2062630004 cites W2071035298 @default.
• W2062630004 cites W2075437346 @default.
• W2062630004 cites W2078993588 @default.
• W2062630004 cites W2083020021 @default.
• W2062630004 cites W2094803435 @default.
• W2062630004 cites W2101259585 @default.
• W2062630004 cites W2115030795 @default.
• W2062630004 cites W2124525707 @default.
• W2062630004 cites W2129800472 @default.
• W2062630004 cites W2136430968 @default.
• W2062630004 cites W2139540775 @default.
• W2062630004 cites W2140846610 @default.
• W2062630004 cites W2145956223 @default.
• W2062630004 cites W2148708125 @default.
• W2062630004 cites W2151884828 @default.
• W2062630004 cites W2157940881 @default.
• W2062630004 cites W2161980441 @default.
• W2062630004 cites W2331320446 @default.
• W2062630004 cites W2342829092 @default.
• W2062630004 cites W2603259205 @default.
• W2062630004 cites W29771769 @default.
• W2062630004 doi "https://doi.org/10.1097/00008571-200411000-00004" @default.
• W2062630004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15564880" @default.
• W2062630004 hasPublicationYear "2004" @default.
• W2062630004 type Work @default.
• W2062630004 sameAs 2062630004 @default.
• W2062630004 citedByCount "150" @default.
• W2062630004 countsByYear W20626300042012 @default.
• W2062630004 countsByYear W20626300042013 @default.
• W2062630004 countsByYear W20626300042014 @default.
• W2062630004 countsByYear W20626300042015 @default.
• W2062630004 countsByYear W20626300042016 @default.
• W2062630004 countsByYear W20626300042017 @default.
• W2062630004 countsByYear W20626300042018 @default.
• W2062630004 countsByYear W20626300042019 @default.
• W2062630004 countsByYear W20626300042020 @default.
• W2062630004 countsByYear W20626300042021 @default.
• W2062630004 countsByYear W20626300042022 @default.
• W2062630004 countsByYear W20626300042023 @default.
• W2062630004 crossrefType "journal-article" @default.
• W2062630004 hasAuthorship W2062630004A5005428001 @default.
• W2062630004 hasAuthorship W2062630004A5014147030 @default.
• W2062630004 hasAuthorship W2062630004A5021773294 @default.
• W2062630004 hasAuthorship W2062630004A5039850816 @default.
• W2062630004 hasAuthorship W2062630004A5044844718 @default.
• W2062630004 hasAuthorship W2062630004A5059206584 @default.
• W2062630004 hasAuthorship W2062630004A5070979458 @default.
• W2062630004 hasAuthorship W2062630004A5073369495 @default.
• W2062630004 hasAuthorship W2062630004A5081600395 @default.
• W2062630004 hasConcept C104317684 @default.
• W2062630004 hasConcept C126322002 @default.
• W2062630004 hasConcept C135763542 @default.
• W2062630004 hasConcept C156957248 @default.
• W2062630004 hasConcept C168007829 @default.
• W2062630004 hasConcept C2777077863 @default.
• W2062630004 hasConcept C2777575956 @default.
• W2062630004 hasConcept C2781059491 @default.
• W2062630004 hasConcept C44249647 @default.
• W2062630004 hasConcept C54355233 @default.
• W2062630004 hasConcept C71924100 @default.
• W2062630004 hasConcept C86803240 @default.
• W2062630004 hasConcept C90924648 @default.
• W2062630004 hasConceptScore W2062630004C104317684 @default.
• W2062630004 hasConceptScore W2062630004C126322002 @default.
• W2062630004 hasConceptScore W2062630004C135763542 @default.
• W2062630004 hasConceptScore W2062630004C156957248 @default.
• W2062630004 hasConceptScore W2062630004C168007829 @default.
• W2062630004 hasConceptScore W2062630004C2777077863 @default.
• W2062630004 hasConceptScore W2062630004C2777575956 @default.

• next