Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062631635> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2062631635 abstract "The effect of acute and chronic morphine administration and naloxone-precipitated withdrawal on the binding of [3H]GABA to its receptor sites in rat brain membranes was investigated. Acute morphine (25 mg/kg) administration produced a decrease in the GABA binding in cerebellum, cortex and striatum. This decrease appears to be due to a selective decrease in the number of high-affinity GABA receptor binding sites. In contrast, rats chronically treated with morphine by pellet implantation did not exhibit any changes in GABA receptor binding, except for an increase in pons medulla. However, in rats which were physically dependent, as indicated by naloxone-precipitated withdrawal, GABA binding was decreased significantly in cerebellum and striatum, relative to chronic morphine treatment or placebo pellet controls. This decrease was due to a decrease in the number of low affinity GABA receptor binding sites. Both chronic morphine and naloxone-precipitated withdrawal treatments produced an increase in GABA binding in the pons medulla. These results suggest that morphine may produce some of its effects by modulating GABAergic systems and that high and low affinity GABA receptor sites may play a differential role during various morphine treatments." @default.
- W2062631635 created "2016-06-24" @default.
- W2062631635 creator A5016230515 @default.
- W2062631635 creator A5045323788 @default.
- W2062631635 date "1980-11-01" @default.
- W2062631635 modified "2023-09-25" @default.
- W2062631635 title "The effects of acute and chronic morphine administration on GABA receptor binding" @default.
- W2062631635 cites W1775749144 @default.
- W2062631635 cites W1939037149 @default.
- W2062631635 cites W1968346353 @default.
- W2062631635 cites W1979385488 @default.
- W2062631635 cites W1990880840 @default.
- W2062631635 cites W2003013600 @default.
- W2062631635 cites W2004075868 @default.
- W2062631635 cites W2012111462 @default.
- W2062631635 cites W2013796683 @default.
- W2062631635 cites W2017710874 @default.
- W2062631635 cites W2035294814 @default.
- W2062631635 cites W2036609848 @default.
- W2062631635 cites W2053793579 @default.
- W2062631635 cites W2059993880 @default.
- W2062631635 cites W2066628109 @default.
- W2062631635 cites W2069996340 @default.
- W2062631635 cites W2075313510 @default.
- W2062631635 cites W2091689165 @default.
- W2062631635 cites W2113727591 @default.
- W2062631635 doi "https://doi.org/10.1016/0014-2999(80)90310-6" @default.
- W2062631635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6258932" @default.
- W2062631635 hasPublicationYear "1980" @default.
- W2062631635 type Work @default.
- W2062631635 sameAs 2062631635 @default.
- W2062631635 citedByCount "44" @default.
- W2062631635 countsByYear W20626316352012 @default.
- W2062631635 countsByYear W20626316352014 @default.
- W2062631635 countsByYear W20626316352015 @default.
- W2062631635 countsByYear W20626316352016 @default.
- W2062631635 countsByYear W20626316352019 @default.
- W2062631635 crossrefType "journal-article" @default.
- W2062631635 hasAuthorship W2062631635A5016230515 @default.
- W2062631635 hasAuthorship W2062631635A5045323788 @default.
- W2062631635 hasConcept C126322002 @default.
- W2062631635 hasConcept C134018914 @default.
- W2062631635 hasConcept C170493617 @default.
- W2062631635 hasConcept C185592680 @default.
- W2062631635 hasConcept C2777389121 @default.
- W2062631635 hasConcept C2778750930 @default.
- W2062631635 hasConcept C2778897929 @default.
- W2062631635 hasConcept C2779177108 @default.
- W2062631635 hasConcept C2779652256 @default.
- W2062631635 hasConcept C2780062018 @default.
- W2062631635 hasConcept C2781063702 @default.
- W2062631635 hasConcept C513476851 @default.
- W2062631635 hasConcept C71924100 @default.
- W2062631635 hasConcept C98274493 @default.
- W2062631635 hasConceptScore W2062631635C126322002 @default.
- W2062631635 hasConceptScore W2062631635C134018914 @default.
- W2062631635 hasConceptScore W2062631635C170493617 @default.
- W2062631635 hasConceptScore W2062631635C185592680 @default.
- W2062631635 hasConceptScore W2062631635C2777389121 @default.
- W2062631635 hasConceptScore W2062631635C2778750930 @default.
- W2062631635 hasConceptScore W2062631635C2778897929 @default.
- W2062631635 hasConceptScore W2062631635C2779177108 @default.
- W2062631635 hasConceptScore W2062631635C2779652256 @default.
- W2062631635 hasConceptScore W2062631635C2780062018 @default.
- W2062631635 hasConceptScore W2062631635C2781063702 @default.
- W2062631635 hasConceptScore W2062631635C513476851 @default.
- W2062631635 hasConceptScore W2062631635C71924100 @default.
- W2062631635 hasConceptScore W2062631635C98274493 @default.
- W2062631635 hasLocation W20626316351 @default.
- W2062631635 hasLocation W20626316352 @default.
- W2062631635 hasOpenAccess W2062631635 @default.
- W2062631635 hasPrimaryLocation W20626316351 @default.
- W2062631635 hasRelatedWork W1971852532 @default.
- W2062631635 hasRelatedWork W2022819458 @default.
- W2062631635 hasRelatedWork W2034583712 @default.
- W2062631635 hasRelatedWork W2053034308 @default.
- W2062631635 hasRelatedWork W2063619316 @default.
- W2062631635 hasRelatedWork W2085356213 @default.
- W2062631635 hasRelatedWork W2088121632 @default.
- W2062631635 hasRelatedWork W2137177585 @default.
- W2062631635 hasRelatedWork W2162607362 @default.
- W2062631635 hasRelatedWork W2355306828 @default.
- W2062631635 isParatext "false" @default.
- W2062631635 isRetracted "false" @default.
- W2062631635 magId "2062631635" @default.
- W2062631635 workType "article" @default.