Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062652813> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2062652813 endingPage "245" @default.
- W2062652813 startingPage "237" @default.
- W2062652813 abstract "In an effort to reconstruct the cellular polarity normally found in the liver, adult rat hepatocytes were sandwiched between two layers of hydrated rat tail tendon collagen matrix. Functionally, sandwiched hepatocytes maintained the secretion of albumin, transferrin, fibrinogen, bile acids, and urea for at least 6 weeks, whereas cells cultured on a single layer of collagen gel ceased such secretion in 1-2 weeks. After 1 week of culture on a single layer of collagen gel, hepatocytes could still recover these lost functions when a second layer of collagen gel was applied. The exact nature of the substrate for constructing the sandwich system appeared to be unimportant as long as it allowed cellular attachment. Hepatocytes cultured in the sandwich system appeared to maintain a distribution of actin filaments similar to the in vivo state, whereas cells cultured on a single layer of collagen gel showed abnormal formation of stress fibers. These studies suggest that simple manipulations of the configuration of extracellular elements can dramatically alter the behavior of cultured hepatocytes." @default.
- W2062652813 created "2016-06-24" @default.
- W2062652813 creator A5008085561 @default.
- W2062652813 creator A5055658784 @default.
- W2062652813 creator A5080742187 @default.
- W2062652813 date "1991-05-01" @default.
- W2062652813 modified "2023-10-02" @default.
- W2062652813 title "Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration" @default.
- W2062652813 doi "https://doi.org/10.1021/bp00009a007" @default.
- W2062652813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1367596" @default.
- W2062652813 hasPublicationYear "1991" @default.
- W2062652813 type Work @default.
- W2062652813 sameAs 2062652813 @default.
- W2062652813 citedByCount "645" @default.
- W2062652813 countsByYear W20626528132012 @default.
- W2062652813 countsByYear W20626528132013 @default.
- W2062652813 countsByYear W20626528132014 @default.
- W2062652813 countsByYear W20626528132015 @default.
- W2062652813 countsByYear W20626528132016 @default.
- W2062652813 countsByYear W20626528132017 @default.
- W2062652813 countsByYear W20626528132018 @default.
- W2062652813 countsByYear W20626528132019 @default.
- W2062652813 countsByYear W20626528132020 @default.
- W2062652813 countsByYear W20626528132021 @default.
- W2062652813 countsByYear W20626528132022 @default.
- W2062652813 countsByYear W20626528132023 @default.
- W2062652813 crossrefType "journal-article" @default.
- W2062652813 hasAuthorship W2062652813A5008085561 @default.
- W2062652813 hasAuthorship W2062652813A5055658784 @default.
- W2062652813 hasAuthorship W2062652813A5080742187 @default.
- W2062652813 hasConcept C106487976 @default.
- W2062652813 hasConcept C12554922 @default.
- W2062652813 hasConcept C150903083 @default.
- W2062652813 hasConcept C185592680 @default.
- W2062652813 hasConcept C189165786 @default.
- W2062652813 hasConcept C202751555 @default.
- W2062652813 hasConcept C207001950 @default.
- W2062652813 hasConcept C22814914 @default.
- W2062652813 hasConcept C2776200302 @default.
- W2062652813 hasConcept C43617362 @default.
- W2062652813 hasConcept C49039625 @default.
- W2062652813 hasConcept C55493867 @default.
- W2062652813 hasConcept C86803240 @default.
- W2062652813 hasConcept C95444343 @default.
- W2062652813 hasConceptScore W2062652813C106487976 @default.
- W2062652813 hasConceptScore W2062652813C12554922 @default.
- W2062652813 hasConceptScore W2062652813C150903083 @default.
- W2062652813 hasConceptScore W2062652813C185592680 @default.
- W2062652813 hasConceptScore W2062652813C189165786 @default.
- W2062652813 hasConceptScore W2062652813C202751555 @default.
- W2062652813 hasConceptScore W2062652813C207001950 @default.
- W2062652813 hasConceptScore W2062652813C22814914 @default.
- W2062652813 hasConceptScore W2062652813C2776200302 @default.
- W2062652813 hasConceptScore W2062652813C43617362 @default.
- W2062652813 hasConceptScore W2062652813C49039625 @default.
- W2062652813 hasConceptScore W2062652813C55493867 @default.
- W2062652813 hasConceptScore W2062652813C86803240 @default.
- W2062652813 hasConceptScore W2062652813C95444343 @default.
- W2062652813 hasIssue "3" @default.
- W2062652813 hasLocation W20626528131 @default.
- W2062652813 hasLocation W20626528132 @default.
- W2062652813 hasOpenAccess W2062652813 @default.
- W2062652813 hasPrimaryLocation W20626528131 @default.
- W2062652813 hasRelatedWork W1987020046 @default.
- W2062652813 hasRelatedWork W2023749098 @default.
- W2062652813 hasRelatedWork W2029823099 @default.
- W2062652813 hasRelatedWork W2035095083 @default.
- W2062652813 hasRelatedWork W2067405618 @default.
- W2062652813 hasRelatedWork W2089360328 @default.
- W2062652813 hasRelatedWork W2159611123 @default.
- W2062652813 hasRelatedWork W2369332797 @default.
- W2062652813 hasRelatedWork W2406668333 @default.
- W2062652813 hasRelatedWork W56184376 @default.
- W2062652813 hasVolume "7" @default.
- W2062652813 isParatext "false" @default.
- W2062652813 isRetracted "false" @default.
- W2062652813 magId "2062652813" @default.
- W2062652813 workType "article" @default.