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- W2062656581 abstract "Chemical and physical agents can lead to selective cytological lesions if the treatment is suitably chosen to dissociate specific target effects from general cytotoxicity involving the whole cell. This chapter discusses the nucleus in the context of ultrastructural modifications taking place after the treatment of cells with various antimetabolites. The specificity of lesions induced by substances having similar molecular action explains the normal structural support by which nucleic acids and proteins are formed, stored, and transported from the nucleus to the cytoplasm. The chapter describes a variety of nuclear inclusions following treatment with 4-nitroquinoline-N-oxide and actinomycin D. The inclusions contain RNA and a large number of proteins; they appear to be formed by a rearrangement of the interchromatin RNP network. Cellular intoxication with heavy metals, such as lead, can also produce nuclear inclusions of a different type. More research should be undertaken on the structural arrangement of the nucleus to investigate its complex functional machinery and the apparent lack of organized framework. The use of models, such as drug-induced lesions and combined structure-function studies are likely to provide more information in the near future." @default.
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- W2062656581 date "1966-08-01" @default.
- W2062656581 modified "2023-09-26" @default.
- W2062656581 title "Effet de l'actinomycine d sur la structure fine du nucléole des hépatocytes de rats intoxiqués par la thioacétamide" @default.
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- W2062656581 doi "https://doi.org/10.1016/0014-4827(66)90405-8" @default.
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