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- W2062656612 abstract "Abstract Background There is evidence for the involvement of platelets under septic conditions. Alterations of platelet surface antigen expression at the onset of septic shock have been reported previously. The aim of this study was to investigate platelet activation as well as changes in platelet receptors during the course of severe sepsis. Methods The study population included six patients with severe sepsis because of peritonitis or necrotizing pancreatitis. Platelet investigations were performed daily. For analysis three characteristic time points during the course were defined restrospectively (A, onset of septic shock; B, significant clinical improvement; C, last sample before death). A double-colour flow cytometric assay was performed in whole blood to determine platelet surface expression of CD63, CD62P, CD42B, CD36 and CD31. Results At the onset of septic shock (A) all patients showed similar antigen expression (CD63, 1·24; CD62P, 0·59; CD42B, 30·9; CD36, 28·0; CD31, 18·2). In surviving patients (B, n = 2) antigen expression was lower (CD63, 0·70; CD62P, 0·38; CD42B, 27·8; CD31, 12·4) or higher (CD36, 27·6) than in patients (C, n = 4) who died (CD63, 1·55; CD62P, 0·72; CD42B, 36·5; CD36, 24·1; CD31, 21·1). Conclusion Although the study population was very small and heterogeneous, these results point to a correlation of platelet surface antigen expression with clinical outcome (survival). It is hypothesized that platelet surface antigen expression, reflecting platelet activation, might be a predictive factor in the course of severe sepsis." @default.
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- W2062656612 date "2000-07-01" @default.
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- W2062656612 title "Evidence of a prognostic value for platelet surface antigen expression in severe abdominal sepsis" @default.
- W2062656612 doi "https://doi.org/10.1046/j.1365-2168.2000.01544-40.x" @default.
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