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• W2062668710 abstract "1. Whole-cell patch clamping was used to study the membrane properties of isolated bipolar cells and the currents evoked in them by putative retinal neurotransmitters. 2. Isolated bipolar cells show an approximately ohmic response to voltage steps over most of the physiological response range, with an average input resistance of 1.3 G omega and resting potential of -35 mV. These values are underestimates because of the shunting effect of the seal between the patch electrode and the cell membrane. Depolarization beyond -30 mV produces rapid activation (10-100 ms) of an outward current (carried largely by potassium ions), which then inactivates slowly (0.5-2 s). 3. Of five candidates for the photoreceptor transmitter, four (aspartate, N-acetylhistidine, cadaverine, putrescine) had no effect on bipolar cells. The fifth substance, L-glutamate, opened ionic channels with a mean reversal potential of -12 mV in some cells (presumed hyperpolarizing bipolar cells), and closed channels with a mean reversal potential of -13 mV in other cells (presumed depolarizing bipolar cells). 4. The conductance increase induced by glutamate in presumed hyperpolarizing bipolar cells was associated with an increase in membrane current noise. Noise analysis suggested a single-channel conductance for the glutamate-gated channel of 5.4 pS. The power spectrum of the noise increase required the sum of two Lorentzian curves to fit it, suggesting that the channel can exist in three states. 5. The conductance decrease induced by glutamate in presumed depolarizing bipolar cells was associated with a decrease in membrane current noise that could be described as the sum of two Lorentzian spectra, and which suggested a single-channel conductance of 11 pS. The noise decrease implies that the channels closed by glutamate are not all open in the absence of the transmitter. 6. GABA (gamma-aminobutyric acid) and glycine, transmitters believed to mediate lateral inhibition in the retina, open chloride channels in isolated bipolar cells, and increase the membrane current noise. Noise analysis suggested that the channels gated by GABA and glycine have conductances of 4.4 and 7.5 pS respectively. The noise spectra required the sum of two Lorentzian curves to fit them. 7. By whole-cell patch clamping cells in retinal slices, the synaptic transmitter released by photoreceptors was shown to close channels with an extrapolated reversal potential around -3 mV in depolarizing bipolar cells.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
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• W2062668710 date "1987-06-01" @default.
• W2062668710 modified "2023-09-27" @default.
• W2062668710 title "Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum." @default.
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• W2062668710 cites W1912845768 @default.
• W2062668710 cites W1963763104 @default.
• W2062668710 cites W1964282119 @default.
• W2062668710 cites W1965554709 @default.
• W2062668710 cites W1970034541 @default.
• W2062668710 cites W1972077152 @default.
• W2062668710 cites W1972866098 @default.
• W2062668710 cites W1977106724 @default.
• W2062668710 cites W1979684921 @default.
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• W2062668710 cites W1990218841 @default.
• W2062668710 cites W1990673766 @default.
• W2062668710 cites W1991020538 @default.
• W2062668710 cites W1991589418 @default.
• W2062668710 cites W1994425265 @default.
• W2062668710 cites W1997511216 @default.
• W2062668710 cites W1997568797 @default.
• W2062668710 cites W2001118184 @default.
• W2062668710 cites W2002926677 @default.
• W2062668710 cites W2003370853 @default.
• W2062668710 cites W2004411419 @default.
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• W2062668710 cites W2007933423 @default.
• W2062668710 cites W2008923589 @default.
• W2062668710 cites W2009667219 @default.
• W2062668710 cites W2015252262 @default.
• W2062668710 cites W2015426350 @default.
• W2062668710 cites W2017784452 @default.
• W2062668710 cites W2019765925 @default.
• W2062668710 cites W2022625411 @default.
• W2062668710 cites W2023220058 @default.
• W2062668710 cites W2024983583 @default.
• W2062668710 cites W2028701130 @default.
• W2062668710 cites W2036704251 @default.
• W2062668710 cites W2041468099 @default.
• W2062668710 cites W2047504426 @default.
• W2062668710 cites W2056527325 @default.
• W2062668710 cites W2060609208 @default.
• W2062668710 cites W2061866061 @default.
• W2062668710 cites W2072060769 @default.
• W2062668710 cites W2073314494 @default.
• W2062668710 cites W2074364727 @default.
• W2062668710 cites W2074798463 @default.
• W2062668710 cites W2080154535 @default.
• W2062668710 cites W2081785456 @default.
• W2062668710 cites W2084071646 @default.
• W2062668710 cites W2084115346 @default.
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• W2062668710 cites W2093575987 @default.
• W2062668710 cites W2095087224 @default.
• W2062668710 cites W2096300326 @default.
• W2062668710 cites W2100548210 @default.
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• W2062668710 doi "https://doi.org/10.1113/jphysiol.1987.sp016567" @default.
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